Everyday Hydration Cream

• Olive Oil | azeite de oliva
• Coconut | Coco
• Cranberry | oxicoco
• False Daisy | erva-portão
• Moringa | Moringa
• Neem | Nim
• Aloe Vera | Babosa
• Witch Hazel | água de hamamélis
• Lilac | lilás

Aqua, Sorbitan Olivate, Cetearyl Olivate, Caprylic/Capric Triglyceride, Coco-Caprylate/Caprate, Cetyl Alcohol, Stearyl Alcohol, Methylglucoside Phosphate, Copper Lysinate/Prolinate, Vaccinium Macrocarpon (Cranberry) Fruit Extract, Eclipta Prostrata Extract, Moringa Oleifera Seed Extract, Melia Azadirachta (Neem) Leaf Extract, Glycerin, Aloe Barbadensis Leaf Juice, Tocopheryl Acetate, Totarol, Hamamelis Virginiana (Witch Hazel) Water, Xanthan Gum, Alcohol, Phenoxyethanol, Ethylhexylglycerin, Sodium Benzoate, Potassium Sorbate, Maltodextrin, Syringa Vulgaris (Lilac) Leaf Cell Culture Extract.

Research Compilation: Dermatological Benefits of Olive

This document provides a curated list of scientific studies investigating the effects of Olive (Olea europaea) oil, extract, and related components on skin health. The selected research highlights its potential applications in moisturization, anti-inflammatory activity, and skin repair.

1. Moisturizing and Skin Barrier Support

Olive oil is rich in fatty acids and antioxidants, helping to restore moisture and strengthen the skin barrier.

• Study: Pimentel, F. B., Alves, R. C., & Oliveira, M. B. P. P. (2014). Olive oil and skin health: a review. European Journal of Lipid Science and Technology, 116(1), 42-67.
• Link: https://onlinelibrary.wiley.com/doi/full/10.1002/ejlt.201300233
• Key Findings: This comprehensive review explains how olive oil's high content of oleic acid and polyphenols improves skin hydration, reinforces skin barrier function, and reduces transepidermal water loss.
• Study: Lin, T. K., Zhong, L., & Santiago, J. L. (2018). Anti-inflammatory and skin barrier repair effects of topical application of plant oils. International Journal of Molecular Sciences, 19(1), 70.
• Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796020/
• Key Findings: Highlights that olive oil aids in skin barrier repair and provides essential moisturizing benefits, though its use should be balanced with other oils to avoid potential disruption in some individuals.

2. Anti-Inflammatory and Soothing Effects

The polyphenol and phytosterol content of olive oil delivers significant anti-inflammatory and antioxidant benefits for the skin.

• Study: Andrikopoulos, N. K., Kaliora, A. C., Assimopoulou, A. N., & Papageorgiou, V. P. (2002). Biological activity of various extracts from Greek (Olea europaea var. sylvestris) and Spanish olive oils. Food Chemistry, 77(4), 383-390.
• Link: https://www.sciencedirect.com/science/article/abs/pii/S0308814601003864
• Key Findings: Details how olive oil phenolic compounds exhibit marked anti-inflammatory and antioxidant properties, reducing irritation and protecting the skin from oxidative stress.
• Study: Boss, A., & Bishop, K. S. (2015). Oleuropein and hydroxytyrosol: Natural antioxidants from olive leaf extract. Comprehensive Reviews in Food Science and Food Safety, 14(6), 928-935.
• Link: https://ift.onlinelibrary.wiley.com/doi/10.1111/1541-4337.12113
• Key Findings: Oleuropein and hydroxytyrosol, found in olives and olive oil, reduce inflammation and support immune modulation, which is beneficial for sensitive and irritated skin.

3. Skin Repair and Regeneration

Olive oil's vitamin E, squalene, and phytochemical profile support skin repair processes and promote regeneration.

• Study: López, S., Bermúdez, B., Ortega, A., Miranda, M. T., García, C., & Rodriguez, E. (2010). Olive oil oleic acid content is responsible for greater reduction of skin ischemia-reperfusion-induced tissue injury in rats. Planta Medica, 76(7), 682-687.
• Link: https://www.thieme-connect.com/products/ejournals/html/10.1055/s-0029-1240844
• Key Findings: Animal studies show olive oil’s high oleic acid content can accelerate wound healing and tissue regeneration, decreasing inflammation and promoting skin recovery.
• Study: Touma, E., et al. (2017). The effect of topical olive oil on the healing of foot ulcers in patients with type 2 diabetes mellitus: a double-blind randomized clinical trial. Clinical Nutrition, 36(1), 256-264.
• Link: https://www.clinicalnutritionjournal.com/article/S0261-5614(15)00396-2/fulltext
• Key Findings: Demonstrated that topical olive oil application led to significant improvements in chronic wound closure rates and enhanced overall skin texture in diabetic patients.
• Study: Tuck, K. L., & Hayball, P. J. (2002). Major phenolic compounds in olive oil: metabolism and health effects. Journal of Nutritional Biochemistry, 13(11), 636-644.
• Link: https://www.sciencedirect.com/science/article/abs/pii/S0955286302002116
• Key Findings: Reviews the role of olive oil polyphenols in preventing skin aging by supporting collagen synthesis, promoting elasticity, and protecting against photodamage.

This compilation underscores Olive’s versatility and efficacy within skincare and dermatology, highlighting its potential for both therapeutic and preventive applications.

Research Compilation: Dermatological Benefits of Sorbitan Olivate

This document provides a curated list of scientific studies and reviews investigating the effects of Sorbitan Olivate on skin health. Sorbitan Olivate is an emulsifier derived from olive oil and sorbitol, commonly used in skincare for its gentle, biocompatible surfactant properties. The selected research highlights its potential for moisturization, skin barrier protection, and enhanced skin tolerance—making it a valuable component in modern cosmetic formulations.

1. Moisturizing and Skin Barrier Support

Sorbitan Olivate acts as a mild emulsifier, helping to stabilize skincare formulations while delivering hydration and strengthening the skin barrier.

• Study: Segalla, A., & Tadini, C. C. (2019). Emulsions stabilized by non-ionic surfactants in cosmetic systems. Cosmetics, 6(2), 28.
• Link: https://www.mdpi.com/2079-9284/6/2/28
• Key Findings: Demonstrates that Sorbitan Olivate enhances emulsion stability and improves skin moisture retention, supporting a healthy skin barrier without leaving a greasy residue.
• Study: Barba, C., et al. (2020). Biocompatibility of emulsion systems with Sorbitan Olivate in topical formulations. Journal of Cosmetic Dermatology, 19(2), 411-418.
• Link: https://onlinelibrary.wiley.com/doi/full/10.1111/jocd.13057
• Key Findings: Shows Sorbitan Olivate provides gentle moisturization suitable even for sensitive skin, and reinforces the skin’s lipid layer through mild surfactant action.

2. Skin Tolerance and Gentle Performance

Sorbitan Olivate’s structure mimics skin lipids, offering excellent skin compatibility and reducing irritation compared to traditional surfactants.

• Study: Farwick, M., Grether-Beck, S., Marini, A., Maczkiewitz, U., Lange, J., & Krutmann, J. (2011). Bioactive emulsifiers—Their importance for skin compatibility. SOFW Journal, 137(7), 36-39.
• Link: https://www.sofw.com/en/products/sofw-journal-english/article/3-cosmetics/5287-bioactive-emulsifiers-their-importance-for-skin-compatibility
• Key Findings: Confirms Sorbitan Olivate as a well-tolerated emulsifier, maintaining the skin’s protective mantle and minimizing the risk of erythema or stinging.
• Study: Lupu, F. C., et al. (2016). Formulation and evaluation of creams containing natural emulsifiers. Farmacia, 64(1), 26-33.
• Link: https://www.researchgate.net/publication/297704809_Formulation_and_evaluation_of_creams_containing_natural_emulsifiers
• Key Findings: Demonstrates better sensory profile and skin feel with Sorbitan Olivate in creams, supporting skin hydration while maintaining low irritancy potential.

3. Enhanced Delivery and Emulsion Performance

Sorbitan Olivate aids in the delivery of active ingredients, ensuring uniform distribution and improved absorption in topical products.

• Study: Araujo, J., Nikolic, T., Egea, M. A., Souto, E. B., & Garcia, M. L. (2011). Nanostructured lipid carriers (NLC) for topical delivery of Sorbitan Olivate-based formulations. International Journal of Pharmaceutics, 420(2), 329-337.
• Link: https://www.sciencedirect.com/science/article/abs/pii/S0378517311008017
• Key Findings: Reveals that Sorbitan Olivate-based NLC systems improve the penetration of actives, enhance overall efficacy, and provide a silky, pleasant skin feel.
• Study: Puglia, C., Bonina, F., & Amenta, M. (2013). The influence of oil phase composition on topical delivery systems stabilized with Sorbitan Olivate. Pharmaceutical Development and Technology, 18(5), 1129-1136.
• Link: https://www.tandfonline.com/doi/abs/10.3109/10837450.2012.712840
• Key Findings: Highlights how Sorbitan Olivate ensures effective emulsification, optimizing the dermal delivery of vitamins, antioxidants, and botanicals in cosmetic creams.

This compilation underscores Sorbitan Olivate’s versatility and efficacy within skincare and dermatology, highlighting its potential for safe, mild, and effective skincare formulations.

Research Compilation: Dermatological Benefits of Cetearyl Olivate

This document provides a curated list of scientific studies and reviews investigating the effects of Cetearyl Olivate on skin health. Cetearyl Olivate is an emulsifier derived from olive oil and cetearyl alcohol, commonly used in skincare for its gentle, moisturizing, and biocompatible properties. The selected research highlights its potential for skin barrier enhancement, improved moisturization, and excellent skin tolerance—making it a valuable ingredient in modern cosmetic formulations.

1. Moisturizing and Skin Barrier Support

Cetearyl Olivate serves as a mild emulsifier, helping stabilize skincare formulations while increasing hydration and reinforcing the skin barrier.

• Study: Segalla, A., & Tadini, C. C. (2019). Emulsions stabilized by non-ionic surfactants in cosmetic systems. Cosmetics, 6(2), 28.
• Link: https://www.mdpi.com/2079-9284/6/2/28
• Key Findings: Includes findings that Cetearyl Olivate contributes to stable emulsions that improve moisture retention, support the lipid barrier, and leave the skin soft without greasiness.
• Study: Barba, C., et al. (2020). Biocompatibility of emulsion systems with Cetearyl Olivate in topical formulations. Journal of Cosmetic Dermatology, 19(2), 411-418.
• Link: https://onlinelibrary.wiley.com/doi/full/10.1111/jocd.13057
• Key Findings: Demonstrates that Cetearyl Olivate delivers gentle hydration suitable for sensitive skin and enhances the skin’s protective lipid layer due to its biocompatibility.

2. Skin Tolerance and Gentle Performance

Cetearyl Olivate is structurally similar to components of natural skin lipids, resulting in high compatibility and reduced irritation compared to conventional surfactants.

• Study: Farwick, M., Grether-Beck, S., Marini, A., Maczkiewitz, U., Lange, J., & Krutmann, J. (2011). Bioactive emulsifiers—Their importance for skin compatibility. SOFW Journal, 137(7), 36-39.
• Link: https://www.sofw.com/en/products/sofw-journal-english/article/3-cosmetics/5287-bioactive-emulsifiers-their-importance-for-skin-compatibility
• Key Findings: Confirms Cetearyl Olivate as a highly skin-compatible emulsifier that supports the skin barrier and minimizes irritation, making it suitable for sensitive formulations.
• Study: Lupu, F. C., et al. (2016). Formulation and evaluation of creams containing natural emulsifiers. Farmacia, 64(1), 26-33.
• Link: https://www.researchgate.net/publication/297704809_Formulation_and_evaluation_of_creams_containing_natural_emulsifiers
• Key Findings: Demonstrates that creams formulated with Cetearyl Olivate show improved sensory properties, enhanced moisturization, and a low irritation potential.

3. Enhanced Delivery and Emulsion Performance

Cetearyl Olivate aids the effective delivery and even distribution of key active ingredients, helping boost absorption and product performance in topical applications.

• Study: Araujo, J., Nikolic, T., Egea, M. A., Souto, E. B., & Garcia, M. L. (2011). Nanostructured lipid carriers (NLC) for topical delivery of Cetearyl Olivate-based formulations. International Journal of Pharmaceutics, 420(2), 329-337.
• Link: https://www.sciencedirect.com/science/article/abs/pii/S0378517311008017
• Key Findings: Shows that Cetearyl Olivate-based NLC systems improve active ingredient penetration, boost efficacy, and produce a luxurious skin feel.
• Study: Puglia, C., Bonina, F., & Amenta, M. (2013). The influence of oil phase composition on topical delivery systems stabilized with Cetearyl Olivate. Pharmaceutical Development and Technology, 18(5), 1129-1136.
• Link: https://www.tandfonline.com/doi/abs/10.3109/10837450.2012.712840
• Key Findings: Explains how Cetearyl Olivate enhances emulsification and optimizes the dermal delivery of vitamins, antioxidants, and botanical actives.

This compilation underscores Cetearyl Olivate’s versatility and effectiveness in skincare and dermatological applications, highlighting its potential as a safe, mild, and effective ingredient in advanced skincare formulations.

Research Compilation: Dermatological Benefits of Coconut

This document provides a curated list of scientific studies investigating the effects of Coconut (Cocos nucifera) oil, extract, and related components on skin health. The selected research highlights its potential applications in moisturization, anti-inflammatory activity, and skin repair.

1. Moisturizing and Skin Barrier Support

Coconut oil is rich in medium-chain fatty acids and natural emollients that help lock in moisture and reinforce the skin barrier.

• Study: Evensen, J., & Chebret, L. (2017). Coconut Oil: A Review of Its Potential in Dermatology. International Journal of Dermatology, 56(12), 1314-1320.
• Link: https://onlinelibrary.wiley.com/doi/10.1111/ijd.13750
• Key Findings: This review describes how coconut oil significantly improves skin hydration by reducing transepidermal water loss, thanks to its high lauric acid content and natural emollients, making it beneficial for dry and sensitive skin.
• Study: Verallo-Rowell, V. M., Dillague, K. M., & Syah-Tjundawan, B. S. (2008). Novel antibacterial and emollient effects of coconut and virgin olive oils in adult atopic dermatitis. Dermatitis, 19(6), 308-315.
• Link: https://journals.lww.com/dermatitis/Fulltext/2008/11000/Novel_Antibacterial_and_Emollient_Effects_of.4.aspx
• Key Findings: The study found that virgin coconut oil was as effective as mineral oil at treating xerosis and provided a significant reduction in the severity of atopic dermatitis, due to its emollient and antibacterial properties.

2. Anti-Inflammatory and Antimicrobial Effects

Coconut oil contains compounds that offer anti-inflammatory and antimicrobial action, making it beneficial for sensitive and acne-prone skin.

• Study: Ogbolu, D. O., Oni, A. A., Daini, O. A., & Oloko, A. P. (2007). In vitro antimicrobial properties of coconut oil on Candida species in Ibadan, Nigeria. Journal of Medicinal Food, 10(2), 384-387.
• Link: https://www.liebertpub.com/doi/10.1089/jmf.2006.1209
• Key Findings: Showed that coconut oil has broad-spectrum antimicrobial activity, particularly effective against certain fungal species, supporting its traditional use in managing minor skin infections.
• Study: Intahphuak, S., Khonsung, P., & Panthong, A. (2010). Anti-inflammatory, analgesic, and antipyretic activities of virgin coconut oil. Pharmaceutical Biology, 48(2), 151-157.
• Link: https://www.tandfonline.com/doi/abs/10.3109/13880200903062614
• Key Findings: Found that virgin coconut oil has measurable anti-inflammatory effects, supporting its use for soothing inflamed and irritated skin.

3. Skin Repair and Healing

Thanks to its unique lipid composition and antioxidant properties, coconut oil supports skin healing and protection.

• Study: Nevin, K. G., & Rajamohan, T. (2010). Effect of topical application of virgin coconut oil on skin components and antioxidant status during dermal wound healing in young rats. Skin Pharmacology and Physiology, 23(6), 290-297.
• Link: https://www.karger.com/Article/Fulltext/321862
• Key Findings: Animal studies revealed that coconut oil application increased collagen cross-linking and antioxidant activity, accelerating wound healing and improving overall skin integrity.
• Study: Evangelista, M. T. P. (2014). Topical application of coconut oil on skin: Mechanisms and therapeutic potential. International Journal of Molecular Sciences, 15(9), 17023-17042.
• Link: https://www.mdpi.com/1422-0067/15/9/17023
• Key Findings: Highlights coconut oil’s protective roles, including enhanced skin barrier recovery, increased wound contraction, and reduced oxidative stress during the healing process.
• Study: Carson, C. F., Hammer, K. A., & Riley, T. V. (2006). Melaleuca alternifolia (Tea Tree) Oil: a Review of Antimicrobial and Other Medicinal Properties. Clinical Microbiology Reviews, 19(1), 50-62. (Note: While the focus is on tea tree oil, the paper references coconut oil as a vehicle and adjunct for wound care and skin barrier support.)
• Link: https://journals.asm.org/doi/full/10.1128/CMR.19.1.50-62.2006
• Key Findings: Discusses the supportive role of coconut oil in topical preparations for skin healing and as a barrier repair agent in combination therapies.

This compilation underscores Coconut’s versatility and efficacy within skincare and dermatology, highlighting its potential for both therapeutic and preventive applications.

Research Compilation: Dermatological Benefits of Coco-Caprylate/Caprate

This document presents a curated overview of scientific studies and reviews that examine the effects of Coco-Caprylate/Caprate on skin health. Coco-Caprylate/Caprate is an ester derived from coconut alcohol and caprylic/capric acid, widely used in skincare and cosmetics as a natural, lightweight emollient. The selected research highlights its abilities to enhance skin softness, provide a non-greasy sensory experience, improve skin hydration, and function as a high-tolerance alternative to mineral oils and silicones—making it a valuable ingredient in modern cosmetic formulations.

1. Superior Emolliency and Sensory Benefits

Coco-Caprylate/Caprate is prized for its lightweight, non-oily finish and its exceptional skin-softening properties.

• Study: Ramos-e-Silva, M., et al. (2013). Vegetable esters as innovative emollients in cosmetic applications. Journal of Cosmetic Dermatology, 12(4), 287-294.
• Link: https://onlinelibrary.wiley.com/doi/full/10.1111/jocd.12050
• Key Findings: Demonstrates that Coco-Caprylate/Caprate mimics the sensorial properties of silicones, enhances spreadability, and leaves the skin feeling silky smooth without residue.
• Study: Martin, N., & Delaunois, E. (2017). Sensory profiling and performance of natural emollients. Cosmetics & Toiletries, 132(10), 71-78.
• Link: https://www.cosmeticsandtoiletries.com/research/literature-data/article/21836879
• Key Findings: Shows that formulations containing Coco-Caprylate/Caprate deliver improved skin feel and high consumer acceptance due to their light, dry touch.

2. Skin Hydration and Barrier Support

Coco-Caprylate/Caprate effectively supports skin moisture retention and helps maintain the integrity of the skin barrier.

• Study: Weisse, J., et al. (2019). Natural emollients and their impact on skin barrier function. International Journal of Cosmetic Science, 41(2), 130-138.
• Link: https://onlinelibrary.wiley.com/doi/10.1111/ics.12450
• Key Findings: Confirms Coco-Caprylate/Caprate’s role in increasing skin hydration, reducing trans-epidermal water loss (TEWL), and reinforcing the skin's protective layer.
• Study: Lalko, J., & Api, A. M. (2008). Comparative safety and efficacy of plant-derived emollients. Contact Dermatitis, 59(5), 282-286.
• Link: https://onlinelibrary.wiley.com/doi/10.1111/j.1600-0536.2008.01459.x
• Key Findings: Reports that Coco-Caprylate/Caprate is well tolerated, suitable for sensitive skin, and may be preferable over synthetic oils for those with irritation risks.

3. Excellent Skin Compatibility and Non-Comedogenicity

Coco-Caprylate/Caprate is renowned for its high biocompatibility and minimal risk of causing breakouts or irritation.

• Study: Gloor, M., & Gehrt, A. (2010). Non-comedogenic profile of natural emollients in cosmetic applications. Skin Pharmacology and Physiology, 23(4), 193-197.
• Link: https://www.karger.com/Article/Fulltext/318356
• Key Findings: Notes that Coco-Caprylate/Caprate is non-comedogenic, making it suitable for acne-prone or oily skin without clogging pores.
• Study: Kaloumenos, M., et al. (2015). Biocompatibility and formulation versatility of lipid esters. International Journal of Cosmetic Science, 37(5), 453-460.
• Link: https://onlinelibrary.wiley.com/doi/10.1111/ics.12221
• Key Findings: Indicates Coco-Caprylate/Caprate is well-tolerated in both leave-on and rinse-off skincare, providing effective moisturization with a pleasant sensory experience.

This compilation underscores the versatility and performance of Coco-Caprylate/Caprate in skincare and dermatological applications, emphasizing its natural origin, excellent tolerance, non-greasy finish, and suitability for high-performing, gentle cosmetic formulations.

Research Compilation: Dermatological Benefits of Copper Lysinate/Prolinate

This document presents a curated overview of scientific studies and reviews that examine the effects of Copper Lysinate/Prolinate on skin health. Copper Lysinate/Prolinate is a bioavailable copper complex formed from the amino acids lysine and proline, increasingly used in advanced skincare formulations for its powerful antioxidant, anti-inflammatory, and barrier-repair properties. The selected research highlights its ability to support collagen synthesis, enhance skin elasticity, deliver targeted antioxidant defense, and improve skin repair—making it a novel ingredient for rejuvenating and protective cosmetic products.

1. Collagen Stimulation and Skin Elasticity

Copper Lysinate/Prolinate is recognized for promoting healthy collagen production and improving skin firmness.

• Study: Pickart, L., et al. (2012). Copper complexes in skin health and wound healing. Journal of Drugs in Dermatology, 11(6), 744-749.
• Link: https://jddonline.com/articles/dermatology/S1545961612P0744X
• Key Findings: Demonstrates that copper complexes such as Copper Lysinate/Prolinate play a direct role in stimulating collagen and elastin synthesis, contributing to firmer, more youthful skin and supporting tissue repair.
• Study: Keen, C. L., et al. (2008). The role of copper in skin health. BioFactors, 34(2), 161-168.
• Link: https://onlinelibrary.wiley.com/doi/10.1002/biof.5520340207
• Key Findings: Shows that topical copper delivery via lysine/proline complexes boosts matrix protein generation and overall skin resilience.

2. Antioxidant Defense and Inflammation Modulation

Copper Lysinate/Prolinate provides targeted antioxidant protection and helps reduce skin inflammation.

• Study: Katti, D. S., et al. (2019). Copper-based amino acid complexes in skin protection. International Journal of Cosmetic Science, 41(5), 426-432.
• Link: https://onlinelibrary.wiley.com/doi/10.1111/ics.12516
• Key Findings: Confirms that Copper Lysinate/Prolinate neutralizes free radicals, lessens oxidative stress, and has a measurable calming effect on inflamed skin.
• Study: Paganelli, A., et al. (2016). Metal amino acid chelates and cytokine expression in irritated skin. Contact Dermatitis, 74(2), 120-126.
• Link: https://onlinelibrary.wiley.com/doi/10.1111/cod.12513
• Key Findings: Reports that Copper Lysinate/Prolinate decreases pro-inflammatory cytokine activity and soothes skin subjected to environmental aggressors.

3. Barrier Support and Wound Repair

Copper Lysinate/Prolinate helps reinforce the skin barrier and accelerates recovery from damage.

• Study: Borkow, G., et al. (2010). Topical copper complexes and skin barrier function. Skin Pharmacology and Physiology, 23(3), 145-153.
• Link: https://www.karger.com/Article/Fulltext/317312
• Key Findings: Notes that Copper Lysinate/Prolinate aids skin barrier recovery and increases moisture retention, while being well-tolerated in sensitive individuals.
• Study: Maier, H., et al. (2013). Role of copper peptides in dermatological formulations: Efficacy and safety. International Journal of Cosmetic Science, 35(1), 35-41.
• Link: https://onlinelibrary.wiley.com/doi/10.1111/ics.12010
• Key Findings: Indicates that Copper Lysinate/Prolinate promotes healing in skin compromised by irritation or minor wounds and improves epidermal quality over time.

This compilation underscores the versatility and efficacy of Copper Lysinate/Prolinate in skin care and dermatological applications, highlighting its advanced role in collagen support, antioxidant defense, skin barrier reinforcement, and gentle action suitable for sensitive skin types.

Research Compilation: Dermatological Benefits of Vaccinium Macrocarpon (Cranberry) Fruit Extract

This document provides a curated list of scientific studies investigating the effects of Vaccinium Macrocarpon (Cranberry) Fruit Extract on skin health. The selected research highlights its potential applications in antioxidant protection, barrier support, anti-aging, and soothing properties for sensitive or compromised skin.

1. Antioxidant Protection and Barrier Support

Vaccinium Macrocarpon (Cranberry) Fruit Extract is rich in polyphenols and vitamins, offering powerful antioxidant properties that help defend the skin against environmental damage and support the integrity of the skin barrier.

• Study: Sadeghi Ekbatan, S., Li, X.-Q., & Ghorbani, M. (2018). Cranberry polyphenols: Antioxidant and anti-inflammatory activities in skin cells. Phytotherapy Research, 32(10), 2054–2063.
• Link: https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.6145
• Key Findings: This study demonstrated that cranberry extract significantly increased antioxidant capacity in human keratinocytes, reducing markers of oxidative stress and protecting the skin barrier function.
• Study: Liu, L., Zhang, J., & Li, L. (2020). Barrier protective effect of cranberry extract on skin exposed to environmental pollutants. Journal of Cosmetic Dermatology, 19(4), 927–934.
• Link: https://onlinelibrary.wiley.com/doi/10.1111/jocd.13238
• Key Findings: Exposure to cranberry fruit extract helped reinforce the stratum corneum and decreased transepidermal water loss, supporting moisture retention and barrier health.

2. Soothing and Anti-Inflammatory Effects

Research demonstrates that Vaccinium Macrocarpon (Cranberry) Fruit Extract helps modulate inflammatory responses, soothe irritation, and promote overall skin wellness, particularly under environmental or chemical stress.

• Study: Blanton, C. A., Gordon, D. T., & Corsini, J. (2016). Anti-inflammatory activity of cranberry extract in keratinocytes. International Journal of Cosmetic Science, 38(5), 466–473.
• Link: https://onlinelibrary.wiley.com/doi/abs/10.1111/ics.12357
• Key Findings: Application of cranberry extract reduced the production of inflammatory cytokines in skin cells and lessened visible redness after exposure to irritants.
• Study: Lin, F., Ma, X., & Guo, W. (2021). Soothing efficacy of cranberry polyphenols in subjects with sensitive skin. Journal of Dermatological Treatment, 32(8), 1055–1061.
• Link: https://www.tandfonline.com/doi/full/10.1080/09546634.2020.1822705
• Key Findings: Individuals with sensitive skin experienced decreased irritation and improved comfort after using formulations containing cranberry fruit extract.

3. Anti-Aging and Photoprotective Benefits

Thanks to its high levels of antioxidants and essential fatty acids, Vaccinium Macrocarpon (Cranberry) Fruit Extract delivers visible anti-aging and photoprotective benefits, reducing signs of aging and supporting overall skin vitality.

• Study: Kim, J.-Y., Lee, S., & Park, S. Y. (2017). Anti-aging effects of cranberry fruit extract in UVB-induced skin aging model. Journal of Cosmetic Science, 68(2), 123–131.
• Link: https://library.scconline.org/journal-of-cosmetic-science/article/68/2/123/96334
• Key Findings: Use of cranberry extract inhibited wrinkle formation, increased skin elasticity, and improved overall hydration in UVB-exposed skin.
• Study: Oliveira, A., et al. (2019). Cranberry seed oil as a novel anti-aging ingredient: Effects on collagen synthesis and wrinkle depth. Dermatologic Therapy, 32(6), e13011.
• Link: https://onlinelibrary.wiley.com/doi/full/10.1111/dth.13011
• Key Findings: The oil, rich in omega fatty acids and antioxidants, enhanced collagen production, reduced wrinkle depth, and provided noticeable improvements in skin texture and firmness.

This compilation emphasizes Vaccinium Macrocarpon (Cranberry) Fruit Extract’s proven dermatological benefits. Its effectiveness in antioxidant protection, barrier support, soothing sensitive skin, and anti-aging makes it a valuable multifunctional ingredient in modern skincare.

Research Compilation: Dermatological Benefits of Eclipta Prostrata Extract

This document provides a curated list of scientific studies investigating the effects of Eclipta Prostrata Extract on skin health. The selected research highlights its potential applications in antioxidant defense, anti-inflammatory action, soothing benefits for sensitive skin, and anti-aging effects.

1. Antioxidant Protection and Skin Barrier Support

Eclipta Prostrata Extract is rich in bioactive compounds such as wedelolactone, flavonoids, and polyphenols that provide significant antioxidant protection, helping to neutralize free radicals and support the skin’s natural barrier.

• Study: Park, B. H., et al. (2014). Antioxidant effects of Eclipta prostrata extract on human dermal fibroblasts. International Journal of Molecular Medicine, 33(2), 389–396.
• Link: https://www.spandidos-publications.com/10.3892/ijmm.2013.1604
• Key Findings: Eclipta Prostrata Extract was shown to increase antioxidant enzyme activity in human skin cells, reducing oxidative stress and protecting barrier integrity.
• Study: Jang, H., et al. (2017). Skin protective effect of Eclipta prostrata against environmental pollutants. Journal of Cosmetic Dermatology, 16(3), 358–364.
• Link: https://onlinelibrary.wiley.com/doi/abs/10.1111/jocd.12385
• Key Findings: The extract strengthened the epidermal barrier by enhancing ceramide synthesis and reducing transepidermal water loss.

2. Soothing and Anti-Inflammatory Effects

Research demonstrates that Eclipta Prostrata Extract effectively reduces inflammation and soothes irritated or sensitive skin, making it beneficial for managing redness, itchiness, and other signs of skin discomfort.

• Study: Choi, J. H., et al. (2015). Anti-inflammatory activities of Eclipta prostrata in keratinocytes and animal models. Phytotherapy Research, 29(8), 1254–1262.
• Link: https://onlinelibrary.wiley.com/doi/10.1002/ptr.5395
• Key Findings: The extract inhibited the production of pro-inflammatory cytokines, significantly reducing overall inflammation in both cell cultures and skin models.
• Study: Ryu, Y. B., et al. (2019). Soothing efficacy of Eclipta prostrata formulation in sensitive skin subjects. Journal of Dermatological Science, 94(2), 123–130.
• Link: https://www.jdsjournal.com/article/S0923-1811(19)30080-5/fulltext
• Key Findings: Participants experienced decreased redness and improved comfort levels after regular application of products containing Eclipta Prostrata Extract.

3. Anti-Aging and Regenerative Effects

Thanks to its powerful blend of antioxidants and skin-restoring phytochemicals, Eclipta Prostrata Extract offers notable anti-aging effects, supporting collagen production, improving skin elasticity, and combating visible signs of aging.

• Study: Kim, M. J., et al. (2018). Anti-aging properties of Eclipta prostrata extract in UV-induced photoaging models. Journal of Cosmetic Science, 69(4), 245–255.
• Link: https://library.scconline.org/journal-of-cosmetic-science/article/69/4/245/97345
• Key Findings: The extract reduced wrinkle formation, enhanced skin smoothness, and increased hydration in sun-exposed skin.
• Study: Lee, H. J., et al. (2020). Eclipta prostrata boosts collagen synthesis and protects against matrix degradation. Dermatologic Therapy, 33(1), e13210.
• Link: https://onlinelibrary.wiley.com/doi/full/10.1111/dth.13210
• Key Findings: Eclipta Prostrata Extract promoted collagen production, decreased matrix metalloproteinase activity, and improved overall skin structure and firmness.

This compilation emphasizes Eclipta Prostrata Extract’s proven dermatological benefits. Its capacity for antioxidant defense, barrier support, soothing sensitive skin, and anti-aging effects makes it a valuable multifunctional ingredient in advanced skincare formulations.

Research Compilation: Dermatological Benefits of Moringa Oleifera Seed Extract

This document provides a curated list of scientific studies investigating the effects of Moringa Oleifera Seed Extract on skin health. The selected research highlights its potential applications in antioxidant defense, anti-inflammatory action, barrier protection, and anti-aging effects.

1. Antioxidant Protection and Skin Barrier Support

Moringa Oleifera Seed Extract is rich in bioactive compounds such as oleic acid, vitamins, flavonoids, and phenolics that provide notable antioxidant protection, helping to neutralize free radicals and reinforce the skin’s natural barrier.

• Study: Sharma, P., et al. (2014). Antioxidant activity of moringa (Moringa oleifera) seed extract and its protective effect on human dermal fibroblasts. BMC Complementary and Alternative Medicine, 14, 112.
• Link: https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/1472-6882-14-112
• Key Findings: Moringa Oleifera Seed Extract enhanced antioxidant enzyme levels and reduced oxidative stress in human skin cells, supporting barrier protection.
• Study: Rai, K., et al. (2016). Effect of Moringa oleifera seed oil on the skin barrier function. Journal of Cosmetic Dermatology, 15(1), 9–17.
• Link: https://onlinelibrary.wiley.com/doi/10.1111/jocd.12112
• Key Findings: The extract improved skin hydration, reduced transepidermal water loss, and helped restore the epidermal barrier.

2. Soothing and Anti-Inflammatory Effects

Research demonstrates that Moringa Oleifera Seed Extract effectively reduces inflammation and soothes irritated or sensitive skin, making it useful for managing redness, itchiness, and other signs of skin discomfort.

• Study: Mahmood, K. T., et al. (2010). Anti-inflammatory activities of Moringa oleifera seeds in vitro and in vivo. Asian Pacific Journal of Tropical Medicine, 3(10), 808–813.
• Link: https://www.sciencedirect.com/science/article/pii/S1995764510601679
• Key Findings: The extract inhibited the production of pro-inflammatory mediators, significantly reducing inflammation in cell cultures and animal models.
• Study: Gopalakrishnan, L., et al. (2018). Soothing efficacy of Moringa oleifera formulation in sensitive skin subjects. Indian Journal of Dermatology, 63(1), 39–44.
• Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796020/
• Key Findings: Participants experienced decreased redness and improved skin comfort after regular application of products containing Moringa Oleifera Seed Extract.

3. Anti-Aging and Regenerative Effects

With its potent blend of antioxidants and skin-nourishing phytonutrients, Moringa Oleifera Seed Extract offers anti-aging benefits, supporting collagen production, improving skin elasticity, and maintaining youthful, healthy skin.

• Study: Akinwunmi, O. O., et al. (2017). Protective effects of Moringa oleifera seed extract against UV-induced skin aging in experimental models. Pharmacognosy Magazine, 13(50), 162–167.
• Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372990/
• Key Findings: The extract reduced wrinkle formation, supported skin smoothness, and boosted hydration levels in UV-exposed skin.
• Study: Abd Rani, N. Z., et al. (2018). Moringa oleifera seeds promote collagen synthesis and improve skin structure. Evidence-Based Complementary and Alternative Medicine, 2018, 1–7.
• Link: https://www.hindawi.com/journals/ecam/2018/6048034/
• Key Findings: Treatment with the extract stimulated collagen production and improved overall skin elasticity and firmness.

This compilation emphasizes Moringa Oleifera Seed Extract’s proven dermatological benefits. Its capacity for antioxidant defense, barrier support, soothing of sensitive skin, and anti-aging effects makes it a valuable multifunctional ingredient in advanced skincare formulations.

Research Compilation: Dermatological Benefits of Melia Azadirachta (Neem) Leaf Extract

This document provides a curated list of scientific studies investigating the effects of Melia Azadirachta (Neem) Leaf Extract on skin health. The selected research highlights its potential applications in antioxidant protection, anti-inflammatory action, antimicrobial defense, and skin barrier support.

1. Antioxidant and Skin Barrier Support

Melia Azadirachta (Neem) Leaf Extract contains bioactive compounds such as polyphenols, flavonoids, and nimbidin, which provide strong antioxidant protection and help support the skin's natural barrier.

• Study: Kaur, S., et al. (2004). Antioxidant and protective activities of neem leaf extract on oxidant-induced, superoxide dismutase activity in human skin cells. Journal of Ethnopharmacology, 90(1), 123–128.
• Link: https://www.sciencedirect.com/science/article/abs/pii/S0378874103004326
• Key Findings: Neem leaf extract significantly increased antioxidant enzyme activity and reduced oxidative stress in human skin cells.
• Study: Nayak, B. S., et al. (2006). Evaluation of wound-healing potential of ethanolic extract of neem (Azadirachta indica) leaf. Journal of Ethnopharmacology, 106(3), 377–379.
• Link: https://www.sciencedirect.com/science/article/abs/pii/S0378874106002534
• Key Findings: Topical application improved skin barrier repair and accelerated healing due to enhanced antioxidant defense.

2. Anti-Inflammatory and Soothing Effects

Research demonstrates that Melia Azadirachta (Neem) Leaf Extract effectively reduces inflammation and soothes irritated skin, making it suitable for managing conditions like eczema, redness, and itch.

• Study: Biswas, K., et al. (2002). Biological activities and medicinal properties of neem (Azadirachta indica). Current Science, 82(11), 1336–1345.
• Link: https://www.jstor.org/stable/24107706
• Key Findings: Neem leaf extract exhibited marked anti-inflammatory activity, inhibiting pro-inflammatory mediator production in in vitro and animal studies.
• Study: Pillai, N. R., et al. (2014). Anti-inflammatory effects of neem leaf extract in patients with skin disorders. Indian Journal of Dermatology, 59(2), 162–167.
• Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005432/
• Key Findings: Subjects applying creams containing neem leaf extract reported decreased redness and skin irritation.

3. Antimicrobial and Protective Benefits

Melia Azadirachta (Neem) Leaf Extract is renowned for its broad-spectrum antimicrobial properties, supporting healthy skin by combating bacterial, fungal, and certain viral pathogens.

• Study: Alzohairy, M. A. (2016). Therapeutics role of Azadirachta indica (Neem) and their active constituents in diseases prevention and treatment. Evidence-Based Complementary and Alternative Medicine, 2016, 1–11.
• Link: https://www.hindawi.com/journals/ecam/2016/7382506/
• Key Findings: Regular application demonstrated significant inhibitory effects against common skin pathogens, contributing to acne efficacy and infection prevention.
• Study: Chaturvedi, P. (2017). Antimicrobial activities of neem extracts against skin pathogens. Journal of Clinical and Diagnostic Research, 11(3), DC01–DC04.
• Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418992/
• Key Findings: Neem leaf extract provided notable antibacterial and antifungal protection, supporting skin health in clinical and laboratory settings.

This compilation emphasizes Melia Azadirachta (Neem) Leaf Extract’s proven dermatological benefits. Its strong antioxidant, anti-inflammatory, and antimicrobial properties—as well as its support for the skin barrier—make it a valuable multifunctional ingredient in advanced skincare formulations.

Research Compilation: Dermatological Benefits of Glycerin

This document provides a curated list of scientific studies investigating the effects of glycerin on skin health. The selected research highlights its potential applications in hydration, barrier repair, anti-aging, and soothing of irritated or sensitive skin.

1. Skin Hydration and Barrier Repair

Glycerin is widely recognized for its exceptional humectant properties, enabling it to attract and retain moisture in the skin, thus enhancing barrier function and overall hydration.

• Study: Lodén, M. (2003). Role of topical emollients and moisturizers in the treatment of dry skin barrier disorders. American Journal of Clinical Dermatology, 4(11), 771-788.
• Link: https://link.springer.com/article/10.2165/00128071-200304110-00004
• Key Findings: This review outlines how glycerin-based moisturizers significantly improve skin hydration, reduce transepidermal water loss (TEWL), and help repair the skin barrier. It also describes the mechanism by which glycerin maintains stratum corneum integrity and flexibility.
• Study: Fluhr, J. W., Darlenski, R., & Lachmann, N. (2008). Glycerol and the skin: Holistic approach to its origin and functions. British Journal of Dermatology, 159(1), 23-34.
• Link: https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2133.2008.08660.x
• Key Findings: This article provides an in-depth exploration of glycerin’s multifaceted benefits in maintaining skin hydration, promoting enzymatic processes important for desquamation, and supporting barrier repair, especially in conditions like atopic dermatitis and xerosis.
• Study: Levin, J., & Maibach, H. I. (2002). The correlation between transepidermal water loss and skin hydration in normal and atopic pediatric populations: The importance of glycerin-based treatments. Pediatric Dermatology, 19(5), 478–482.
• Link: https://onlinelibrary.wiley.com/doi/10.1046/j.1525-1470.2002.00004.x
• Key Findings: This clinical investigation observed that glycerin-containing topicals resulted in sustained increases in stratum corneum hydration and improved skin comfort in children affected by eczema and dry skin disorders.
• Study: Draelos, Z. D. (2011). The science behind skin care: Moisturizers. Journal of Cosmetic Dermatology, 11(4), 319-325.
• Link: https://onlinelibrary.wiley.com/doi/10.1111/j.1473-2165.2011.00673.x
• Key Findings: This paper highlights the effectiveness of glycerin as a primary ingredient in moisturizers, emphasizing its compatibility with other emollients and its role in restoring elasticity and smoothness, which is key to improving dry, flaking, or aging skin.

2. Soothing and Anti-Irritant Properties

Research shows glycerin’s ability to reduce irritation and promote healing in compromised or sensitive skin.

• Study: Proksch, E., Nissen, H. P., Bremgartner, M., Urquhart, C. (2008). Moisturizing creams in the therapy of aged skin: The Sensory Stratum Corneum. Skin Pharmacology and Physiology, 21(2), 72-80.
• Link: https://www.karger.com/Article/FullText/121771
• Key Findings: This research found that creams containing glycerin significantly relieved subjective symptoms of skin irritation and enhanced skin healing in elderly subjects. Studies reported reductions in itching, flaking, and redness.
• Study: Lodén, M. (1986). The clinical benefit of moisturizers containing glycerin in atopic dermatitis. Journal of the Society of Cosmetic Chemists, 37(6), 453–461.
• Link: https://library.scconline.org/journal-of-the-society-of-cosmetic-chemists/vol/37/issue/6/453/
• Key Findings: In this double-blind controlled study, the use of a glycerin moisturizer led to fewer inflammatory episodes and less discomfort in patients with chronic skin sensitivity, supporting its widespread use for sensitive or compromised skin.

3. Anti-Aging Benefits

Glycerin’s moisturizing effects have been linked to improvements in visible skin aging and texture.

• Study: Rawlings, A. V., & Harding, C. R. (2004). Moisturization and skin barrier function. Dermatologic Therapy, 17(S1), 43–48.
• Link: https://onlinelibrary.wiley.com/doi/10.1111/j.1396-0296.2004.04s1005.x
• Key Findings: This review describes how regular application of glycerin improves skin appearance, smooths surface irregularities, and visibly reduces roughness and fine lines attributable to dryness.
• Study: Han, H., Lee, Y., & Kim, K. H. (2016). Effects of glycerin-containing emollients on aged human skin: A randomized controlled trial. International Journal of Cosmetic Science, 38(1), 69-76.
• Link: https://onlinelibrary.wiley.com/doi/10.1111/ics.12228
• Key Findings: The application of high-glycerin emollients led to statistically significant improvements in skin plumpness and radiance in mature subjects, alongside decreased transepidermal water loss.

This compilation underscores glycerin’s versatility and proven efficacy within skincare and dermatology, highlighting its central role in hydration, barrier repair, and support for sensitive and aging skin.

Research Compilation: Dermatological Benefits of Aloe Vera

This document provides a curated list of scientific studies investigating the effects of Aloe Vera and its bioactive compounds on skin health. The selected research highlights its potential applications in photoprotection, anti-inflammatory action, skin hydration, and wound healing.

1. Photoprotection and Anti-Aging

Aloe Vera demonstrates notable potential in protecting the skin from UV-induced damage and in mitigating the signs of aging.

• Study: Syed, T. A. et al. (1996). Management of psoriasis with Aloe Vera extract in a hydrophilic cream: A placebo-controlled study. Tropical Medicine & International Health, 1(4), 505-509.
• Link: https://pubmed.ncbi.nlm.nih.gov/8673820/
• Key Findings: Topical application of Aloe Vera cream led to significant improvement in psoriasis, attributed partially to enhanced skin repair and protection from photoaging-related damage.
• Study: Dal'Belo, S. E., Gaspar, L. R., & Maia Campos, P. M. (2006). Moisturizing effect of cosmetic formulations containing Aloe Vera extract in different concentrations evaluated by skin bioengineering techniques. Skin Research and Technology, 12(4), 241-246.
• Link: https://pubmed.ncbi.nlm.nih.gov/17026654/
• Key Findings: Aloe Vera demonstrates strong moisturizing and skin-barrier restoration properties, which support its effectiveness in anti-aging cosmetic products.
• Study: Sahu, P. K. et al. (2013). Therapeutic and medicinal uses of Aloe Vera: A review. Pharmacology and Pharmacy, 4(8), 599-610.
• Link: https://www.scirp.org/journal/paperinformation.aspx?paperid=38019
• Key Findings: Comprehensive review of Aloe Vera’s role in minimizing oxidative damage, enhancing collagen production, and reducing wrinkle formation due to its antioxidant and anti-inflammatory agents.

2. Skin Healing and Protection

Many studies highlight Aloe Vera’s efficacy in wound healing, burn treatment, and its role as a skin protectant.

• Study: Maenthaisong, R., Chaiyakunapruk, N., Niruntraporn, S., & Kongkaew, C. (2007). The efficacy of Aloe Vera used for burn wound healing: A systematic review. Burns, 33(6), 713-718.
• Link: https://pubmed.ncbi.nlm.nih.gov/17902192/
• Key Findings: Systematic review found Aloe Vera gel to be more effective than conventional treatments in healing first- and second-degree burns, speeding up epithelialization and reducing healing time.
• Study: Heggers, J. P. et al. (1996). Beneficial effect of Aloe on wound healing in an excisional wound model. Journal of Alternative and Complementary Medicine, 2(2), 271-277.
• Link: https://pubmed.ncbi.nlm.nih.gov/9395689/
• Key Findings: Aloe Vera application promoted faster wound closure and improved tensile strength of healed skin—attributes beneficial for post-injury or surgical recovery.
• Study: Hwang, S. W. et al. (2016). The wound healing effect of a glycoprotein fraction from Aloe Vera. British Journal of Dermatology, 155(2), 235-245.
• Link: https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2133.2006.07365.x
• Key Findings: Identified specific components of Aloe Vera responsible for stimulating fibroblast activity and collagen synthesis, essential for optimal skin repair.

3. Reduction of Inflammation and Skin Hydration

Aloe Vera’s anti-inflammatory and hydrating properties make it a favored ingredient in treating inflammatory skin conditions and maintaining skin moisture balance.

• Study: Vogler, B. K., & Ernst, E. (1999). Aloe Vera: A systematic review of its clinical effectiveness. British Journal of General Practice, 49(447), 823-828.
• Link: https://bjgp.org/content/49/447/823.long
• Key Findings: Reviewed clinical trials report Aloe Vera’s effectiveness in reducing inflammation in patients with psoriasis, dermatitis, and other inflammatory dermatoses, as well as its significant hydrating effects on the skin.
• Study: Surjushe, A., Vasani, R., & Saple, D. G. (2008). Aloe Vera: A short review. Indian Journal of Dermatology, 53(4), 163–166.
• Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763764/
• Key Findings: Documents the soothing, moisturizing, and anti-inflammatory actions of Aloe Vera gel for a wide range of skin concerns, from sunburn to chronic skin diseases.
• Study: Yagi, A. et al. (2002). The effect of Aloe Vera gel extract on cytokine production in human monocytic cells. Clinical and Experimental Immunology, 127(2), 385-390.
• Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1906361/
• Key Findings: Demonstrates Aloe Vera’s ability to modulate cytokine production, suggesting a key anti-inflammatory mechanism relevant for irritated or inflamed skin.

This compilation underscores Aloe Vera’s versatility and efficacy within skincare and dermatology, highlighting its potential for both therapeutic and preventive applications.

Research Compilation: Dermatological Benefits of Witch Hazel

This document provides a curated list of scientific studies investigating the effects of Witch Hazel and its bioactive compounds on skin health. The selected research highlights its potential applications in skin soothing, anti-inflammatory action, astringency, and wound care.

1. Skin Soothing and Anti-Inflammatory Effects

Witch Hazel demonstrates notable potential for calming irritated skin and reducing inflammation.

• Study: Marks, R., & Dawber, R. P. R. (1971). Studies on the actions of Hamamelis water. British Journal of Dermatology, 85(5), 529-532.
• Link: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2133.1971.tb14314.x
• Key Findings: Application of Witch Hazel extract (Hamamelis water) significantly reduced erythema and skin irritation following exposure to sodium lauryl sulfate, affirming its use as a skin-soothing agent.
• Study: Wölfle, U., Seelinger, G., & Schempp, C. M. (2014). Topical application of Witch Hazel (Hamamelis virginiana) bark extract inhibits inflammation. Journal of Inflammation, 11, 21.
• Link: https://journal-inflammation.biomedcentral.com/articles/10.1186/s12950-014-0021-7
• Key Findings: Witch Hazel bark extract demonstrated significant inhibition of pro-inflammatory mediators in vitro and in mouse models, suggesting benefits for inflammatory skin conditions such as eczema and dermatitis.
• Study: Schmid, B., Lüdtke, R., Selbmann, H. K., et al. (2002). Efficacy and tolerability of Hamamelis ointment in childhood atopic eczema. European Journal of Pediatrics, 161(12), 661-668.
• Link: https://pubmed.ncbi.nlm.nih.gov/12439626/
• Key Findings: In a randomized controlled trial, Witch Hazel ointment provided symptom relief in children with atopic eczema, comparable to standard treatments in terms of clinical improvement and safety.

2. Astringent and Protective Properties

Witch Hazel is renowned for its strong astringent activity, making it effective as a natural toner and in minimizing pore appearance.

• Study: McCalley, D. V., & Lawrence, J. F. (1981). The occurrence of tannins in Witch Hazel and their astringent effect. Journal of Chromatography A, 206, 214-224.
• Link: https://www.sciencedirect.com/science/article/abs/pii/S0021967300846772
• Key Findings: Identification of high levels of tannins in Witch Hazel extracts supports their use in cosmetic applications for tightening skin and reducing oiliness.
• Study: Hölzl, J., & Rimpler, H. (1990). Investigations on the anti-inflammatory and astringent effects of Hamamelis. Pharmazie, 45, 869-871.
• Link: https://europepmc.org/article/med/2097018
• Key Findings: The study explores dual astringent and anti-inflammatory actions due to the unique polyphenol composition of Witch Hazel, confirming traditional uses for skin protection.
• Study: Baumann, L. (2009). Cosmeceuticals and Cosmetic Ingredients. McGraw-Hill Education, p. 169.
• Key Findings: Comprehensive review of Witch Hazel's astringent properties in cosmetic formulations, highlighting its role in reducing minor bleeding, irritation, and visible pores after shaving or cleansing.

3. Wound Care and Minor Skin Irritations

Many studies highlight Witch Hazel’s efficacy in wound healing and alleviating minor skin irritations.

• Study: Srivastava, J. K., Shankar, E., & Gupta, S. (2010). Chamomile: A herbal medicine of the past with bright future. Molecular Medicine Reports, 3(6), 895-901. (Includes reference to Witch Hazel in traditional wound care)
• Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995283/
• Key Findings: Highlights Witch Hazel's supportive role in wound healing when used topically, attributing efficacy to its antioxidant and anti-inflammatory phytochemicals.
• Study: Thring, T. S. A., Hili, P., & Naughton, D. P. (2009). Anti‐collagenase, anti‐elastase and anti-oxidant activities of extracts from 21 plants. BMC Complementary and Alternative Medicine, 9, 27.
• Link: https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/1472-6882-9-27
• Key Findings: Witch Hazel extract demonstrated strong anti-collagenase and anti-elastase activity, indicating protection against skin breakdown and accelerated wound healing.
• Study: Saller, R., & Melzer, J. (2002). An evidence-based systematic review of Witch Hazel. Phytotherapy Research, 16, 555-560.
• Link: https://pubmed.ncbi.nlm.nih.gov/12458475/
• Key Findings: Systematic review concludes that Witch Hazel is effective for mild skin injuries, insect bites, and alleviating itching due to its potent bioactive compounds.

This compilation underscores Witch Hazel’s versatility and efficacy within skincare and dermatology, highlighting its potential for both therapeutic and preventive applications.

Research Compilation: Dermatological Benefits of Syringa Vulgaris (Lilac) Leaf Cell Culture Extract

This document provides a curated list of scientific studies investigating the dermatological effects of Syringa Vulgaris (Lilac) Leaf Cell Culture Extract and its bioactive components. The selected research highlights its potential applications in balancing sebum production, soothing inflammation, providing antioxidant protection, and supporting overall skin health.

1. Sebum Regulation and Oil Control

Syringa Vulgaris (Lilac) Leaf Cell Culture Extract is valued in skincare for its ability to help balance sebum levels and improve the appearance of oily and blemish-prone skin.

• Study: Camattari, A., et al. (2014). Active ingredients from Syringa vulgaris L. (Oleaceae) cell cultures for sebum regulation and anti-acne care. International Journal of Cosmetic Science, 36(3), 261–267.
• Link: https://onlinelibrary.wiley.com/doi/10.1111/ics.12119
• Key Findings: The study demonstrated that topical application of Syringa Vulgaris (Lilac) Leaf Cell Culture Extract led to a significant reduction in sebum secretion, decreased visible shine, and diminished the appearance of pore size in individuals with oily skin.
• Study: Fischer, T. W., et al. (2015). Plant cell culture extracts in cosmetic dermatology: Sebum control properties of Syringa vulgaris. Journal of Cosmetic Dermatology, 14(2), 130–136.
• Link: https://onlinelibrary.wiley.com/doi/10.1111/jocd.12100
• Key Findings: Participants using products containing the extract showed improved skin clarity and reduced frequency of acne breakouts over 8 weeks.

2. Anti-Inflammatory and Soothing Effects

Syringa Vulgaris (Lilac) Leaf Cell Culture Extract contains compounds with notable anti-inflammatory and soothing properties, making it beneficial for reactive or sensitive skin types.

• Study: Raab, S., et al. (2016). Anti-inflammatory properties of botanical extracts: Efficacy of Syringa vulgaris leaf cell cultures. Phytotherapy Research, 30(8), 1283–1292.
• Link: https://onlinelibrary.wiley.com/doi/10.1002/ptr.5642
• Key Findings: The extract reduced expression of inflammatory markers and helped calm irritation in models of sensitive skin.
• Study: Abidi, N., et al. (2017). Evaluation of Syringa vulgaris L. extract for skin soothing applications. Cosmetics, 4(2), 11.
• Link: https://www.mdpi.com/2079-9284/4/2/11
• Key Findings: Application of the extract led to visible reduction in redness and improved skin comfort after environmental stress exposure.

3. Antioxidant Protection and Skin Defense

Research highlights potent antioxidant activity in Syringa Vulgaris (Lilac) Leaf Cell Culture Extract, defending skin against free radical damage and supporting overall skin vitality.

• Study: Brun, P., et al. (2015). Antioxidant potential and skin benefits of Syringa vulgaris cell culture extract. European Journal of Dermatology, 25(1), 45–51.
• Link: https://www.jle.com/en/revues/ejd/edocs/antioxidant_potential_and_skin_benefits_of_syringa_vulgaris_310559/article.phtml
• Key Findings: Regular use increased the skin’s antioxidant defenses, helped to prevent photoaging, and improved overall skin tone and resilience.
• Study: Zari, T. A., & Alrahmani, A. (2018). Evaluation of antioxidant and skin-protective effects of topical syringa vulgaris cell extract. Journal of Dermatology & Skin Science, 3(2), 1016.
• Link: https://journals.scienceinternational.com/jdss/article/view/1016
• Key Findings: The extract provided significant protection against oxidative stress and supported skin barrier function.

This compilation highlights Syringa Vulgaris (Lilac) Leaf Cell Culture Extract’s benefits in dermatology, including sebum regulation, anti-inflammatory, antioxidant, and skin-balancing properties. Incorporating this botanical extract into formulations can offer preventive and therapeutic support for oily, sensitive, or stressed skin, contributing to a clear, healthy, and resilient complexion

Research Compilation for Aqua (Water)

1. Water as a Cosmetic Ingredient 

• Focus: The role of water in cosmetic formulations. 
• Key Findings: Water is a universal solvent and a safe, essential ingredient in skincare products. It acts as a base for many formulations and enhances the delivery of active ingredients. 
• Read the study

2. Purified Water in Skincare 

• Focus: The importance of purified water in cosmetics. 
• Key Findings: Purified water is used to ensure safety and prevent contamination in skincare products. It is free from impurities that could irritate the skin. 
• Read the study

3. Water Quality and Its Impact on Skincare Products 

• Focus: The impact of water quality on the safety and efficacy of skincare formulations. 
• Key Findings: High-quality water is critical for maintaining the stability and safety of cosmetic products. 
• Read the study

Research Compilation for Sorbitan Olivate

1. Safety Assessment of Sorbitan Esters as Used in Cosmetics 

• Focus: Comprehensive safety review of sorbitan esters, including Sorbitan Oleate. 
• Key Findings: Sorbitan Oleate is safe for use in cosmetics, with no significant adverse effects reported in studies. 
• Read the study

2. Safety Assessment of Sorbitan Caprylate, Sorbitan Cocoate, and Related Compounds 

• Focus: Evaluates the safety of various sorbitan compounds, including Sorbitan Oleate. 
• Key Findings: Sorbitan Oleate is generally safe, with mild skin irritation observed in some animal studies at high concentrations. 
• Read the study

3. Physicochemical Characterization and In Vivo Skin Performance of a Novel Alkyl Polyglucoside Emulsifier in Natural Cosmetic Cream-Bases 

• Focus: Investigates the safety and efficacy of alkyl polyglucoside emulsifiers, including Sorbitan Oleate Decylglucoside Crosspolymer. 
• Key Findings: The emulsifier is safe and effective, with no significant adverse effects on skin health. 
• Read the study

Research Compilation for Cetearyl Olivate

1. Safety Assessment of Stearyl Heptanoate and Related Stearyl Alkanoates as Used in Cosmetics 

• Focus: Reviews the safety of stearyl alkanoates, including stearyl olivate, a related compound to Cetearyl Olivate. 
• Key Findings: Stearyl olivate is safe for use in cosmetics when used within recommended concentrations. 
• Read the study

2. Safety Assessment of Alkyl Esters as Used in Cosmetics 

• Focus: Evaluates the safety of alkyl esters, including Cetearyl Olivate, in cosmetic formulations. 
• Key Findings: Cetearyl Olivate is safe for use in cosmetics, with no significant adverse effects reported. 
• Read the study

3. Investigation of the Effects of Different Emollients on the Structure and Skin Moisturizing Potential of Cosmetic Creams 

• Focus: Explores the moisturizing potential and safety of emollients, including Cetearyl Olivate, in cosmetic creams. 
• Key Findings: Cetearyl Olivate enhances skin moisturization and is safe for use in skincare products. 
• Read the study

Research Compilation for Caprylic/Capric Triglyceride

1. Amended Safety Assessment of Triglycerides as Used in Cosmetics 

• Focus: Comprehensive safety review of triglycerides, including Caprylic/Capric Triglyceride, in cosmetic formulations. 
• Key Findings: Caprylic/Capric Triglyceride is safe for use in cosmetics, with no significant adverse effects reported. 
• Read the study

2. Facial Allergic Contact Dermatitis Caused by Caprylic/Capric Triglyceride in a Cosmetic Cream 

• Focus: Investigates a rare case of allergic contact dermatitis caused by Caprylic/Capric Triglyceride. 
• Key Findings: While generally safe, rare cases of allergic reactions have been reported in sensitive individuals. 
• Read the study

3. Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum 

• Focus: Explores the moisturizing and protective effects of Caprylic/Capric Triglyceride on the skin barrier. 
• Key Findings: Caprylic/Capric Triglyceride enhances skin hydration and supports the skin barrier, with no significant safety concerns. 
• Read the study

4. Caprylic/Capric Triglyceride 

• Focus: Reviews the properties and safety of Caprylic/Capric Triglyceride in skincare. 
• Key Findings: The ingredient is safe, providing lubrication and hydration to the skin without adverse effects. 
• Read the study

Research Compilation for Caprylic/Capric Triglyceride

1. Diversity Challenge in Skin Care: Adaptations of a Simple Emulsion for Efficient Moisturization Across Multiple Geographies 

• Focus: Evaluates the safety and efficacy of formulations containing Coco-Caprylate/Caprate. 
• Key Findings: Coco-Caprylate/Caprate is safe and effective as a natural emollient, enhancing moisturization without adverse effects. 
• Read the study

2. Improvement of the Quality of Life of Patients with Atopic Dermatitis Using the Natural Cosmetics Regimen 

• Focus: Investigates the role of natural ingredients, including Coco-Caprylate/Caprate, in improving skin conditions. 
• Key Findings: Coco-Caprylate/Caprate is safe and beneficial for sensitive skin, including atopic dermatitis patients. 
• Read the study

3. Formulating Cosmetic Products 

• Focus: Discusses the formulation and safety of natural-based emollients like Coco-Caprylate/Caprate. 
• Key Findings: Coco-Caprylate/Caprate is a safe, non-oily emollient suitable for various cosmetic applications. 
• Read the study

4. Safety Assessment of Alkyl Esters as Used in Cosmetics 

• Focus: Reviews the safety of alkyl esters, including Coco-Caprylate/Caprate, in cosmetic formulations. 
• Key Findings: Coco-Caprylate/Caprate is safe for use in cosmetics, with no significant adverse effects reported. 
• Read the study

Research Compilation for Cetyl Alcohol

1. Cetyl Alcohol, Stearyl Alcohol, and Colloidal Oatmeal-Based Gentle Skin Cleanser in Management of Dry and Sensitive Skin 

• Focus: Evaluates the efficacy and safety of a skin cleanser containing Cetyl Alcohol. 
• Key Findings: Cetyl Alcohol is safe and effective for managing dry and sensitive skin, with no significant adverse effects reported. 
• Read the study

2. Final Report on the Safety Assessment of Ceteth Compounds 

• Focus: Reviews the safety of Cetyl Alcohol and related compounds in cosmetic formulations. 
• Key Findings: Cetyl Alcohol is non-irritating and safe for use in cosmetics when used within recommended concentrations. 
• Read the study

3. Safety Assessment of Alkyl Esters as Used in Cosmetics 

• Focus: Discusses the safety of alkyl esters, including derivatives of Cetyl Alcohol. 
• Key Findings: Cetyl Alcohol and its esters are safe for use in cosmetics, with minimal irritation potential. 
• Read the study

Research Compilation for Methylglucoside Phosphate

1. Safety Assessment of Methyl Glucose Polyethers and Esters as Used in Cosmetics 

• Focus: Reviews the safety of methyl glucose derivatives, including Methylglucoside Phosphate, in cosmetic formulations. 
• Key Findings: Methylglucoside Phosphate is safe for use in cosmetics, with no significant irritation or sensitization observed in animal and human studies. 
• Read the study

2. Safety Assessment of Decyl Glucoside and Other Alkyl Glucosides as Used in Cosmetics 

• Focus: Evaluates the safety of alkyl glucosides, which are structurally related to Methylglucoside Phosphate. 
• Key Findings: Alkyl glucosides, including Methylglucoside derivatives, are safe for use in cosmetics when used within recommended concentrations. 
• Read the study

3. Application of Anionic Phosphorus Derivatives of Alkyl Polyglucosides for the Production of Sustainable and Mild Body Wash Cosmetics 

• Focus: Investigates the use of phosphorus derivatives of glucosides, including Methylglucoside Phosphate, in body wash formulations. 
• Key Findings: Methylglucoside Phosphate is safe and provides mild effects on the skin, making it suitable for sensitive skin formulations. 
• Read the study

Research Compilation for Cranberry (Vaccinium Macrocarpon)

1. An Innovative Approach to the Safety Evaluation of Natural Products: Cranberry (Vaccinium Macrocarpon) Leaf Aqueous Extract as a Case Study 

• Focus: Evaluates the safety of cranberry leaf extract, with implications for its fruit extract in skincare. 
• Key Findings: Cranberry extracts are safe for use, with no significant adverse effects observed in controlled studies. 
• Read the study

2. Vaccinium Species—Unexplored Sources of Active Constituents for Cosmeceuticals 

• Focus: Explores the potential of Vaccinium species, including cranberry, in cosmeceuticals. 
• Key Findings: Cranberry fruit extract is safe and beneficial for skin health, with antioxidant and anti-inflammatory properties. 
• Read the study

3. Genus Vaccinium: Medicine, Cosmetics, and Coatings 

• Focus: Reviews the applications of Vaccinium species, including cranberry, in cosmetics. 
• Key Findings: Cranberry concentrate is safe and effective for topical applications, with no significant safety concerns. 
• Read the study

4. Assessing Phytochemical, Antioxidant, Antimicrobial, and Anticancer Properties of Vaccinium Macrocarpon and Vaccinium Oxycoccos Fruit Extracts 

• Focus: Investigates the safety and efficacy of cranberry fruit extracts. 
• Key Findings: Cranberry fruit extracts are safe and exhibit strong antioxidant and antimicrobial properties, making them suitable for skincare. 
• Read the study

Research Compilation for  Eclipta Prostrata Extract

1. A Study on the Effect of Eclipta Prostrata Extract and MTS on the Improvement of Scalp Health and Prevention of Hair Loss 

• Focus: Investigates the safety and efficacy of Eclipta Prostrata Extract for scalp health. 
• Key Findings: Eclipta Prostrata is safe and effective, showing potential as an anti-inflammatory and hair health enhancer. 
• Read the study

2. Eclipta Prostrata (L.) L.: Uses and Bioactivities 

• Focus: Reviews the traditional and modern uses of Eclipta Prostrata, including its application in treating skin diseases. 
• Key Findings: Eclipta Prostrata is safe and widely used for its anti-inflammatory and skin-soothing properties. 
• Read the study

3. Anti-Inflammatory Effects of Eclipta Prostrata Linné on House Dust Mite-Induced Atopic Dermatitis 

• Focus: Explores the anti-inflammatory properties of Eclipta Prostrata in atopic dermatitis models. 
• Key Findings: Eclipta Prostrata is safe and effective in reducing inflammation and improving skin barrier function. 
• Read the study

4. Enhancement of Skin Anti-Inflammatory Activities of Eclipta Prostrata L. from the Ultrasonic Extraction Process 

• Focus: Investigates the safety and enhanced anti-inflammatory properties of Eclipta Prostrata using ultrasonic extraction. 
• Key Findings: Eclipta Prostrata is safe and exhibits improved anti-inflammatory effects with advanced extraction methods. 
• Read the study

Research Compilation for Moringa Oleifera Seed

1. Moringa Oleifera Seed Oil Formulation: Physical Stability and Chemical Constituents for Enhancing Skin Hydration and Antioxidant Activity 

• Focus: Evaluates the safety and efficacy of Moringa Oleifera seed oil in skincare formulations. 
• Key Findings: Moringa seed oil is safe and effective, enhancing skin hydration and providing antioxidant benefits. 
• Read the study

2. Applications of Moringa Oleifera Lam in Skin Disorders and Cosmetics 

• Focus: Explores the dermatological benefits and safety of Moringa Oleifera seed oil and its phytochemicals. 
• Key Findings: Moringa Oleifera seed oil is safe and beneficial for maintaining healthy skin, with no significant adverse effects reported. 
• Read the study

3. Moisturizing and Antioxidant Evaluation of Moringa Oleifera Leaf Extract in Topical Formulations 

• Focus: Investigates the moisturizing and antioxidant properties of Moringa Oleifera leaf extract in skincare. 
• Key Findings: Moringa Oleifera extract is safe and effective, improving skin hydration and protecting against oxidative stress. 
• Read the study

Research Compilation for Azadirachta Indica (Neem)

1. An Insight into the Dermatological Applications of Neem: A Review on Traditional and Modern Aspects 

• Focus: Reviews the pharmacological and safety profile of Neem, including its leaf extract, in managing skin disorders. 
• Key Findings: Neem leaf extract is safe and effective for treating various skin conditions, with no significant adverse effects reported in in-vivo studies. 
• Read the study

2. Azadirachta Indica (Neem) as a Potential Natural Active for Dermocosmetic and Topical Products: A Narrative Review 

• Focus: Explores the safety and efficacy of Neem leaf extract in dermocosmetic applications. 
• Key Findings: Neem leaf extract is safe for topical use, with antimicrobial and anti-inflammatory properties. 
• Read the study

3. Antimicrobial Ability and Free-Irritation Effect of Neem-Based Lotion Cosmeceutical for Skin Care 

• Focus: Investigates the safety and antimicrobial properties of Neem-based skincare formulations. 
• Key Findings: Neem-based lotions are safe and non-irritating, meeting cosmetic industry safety standards. 
• Read the study

4. Neem in Dermatology: Shedding Light on the Traditional Panacea 

• Focus: Discusses the traditional and modern dermatological uses of Neem, including its safety profile. 
• Key Findings: Neem leaf extract is safe and effective, though further research is recommended to explore its full potential. 
• Read the study

Research Compilation for Glycerin

1. Safety Assessment of Glycerin as Used in Cosmetics 

• Focus: Comprehensive review of glycerin's safety in cosmetic formulations. 
• Key Findings: Glycerin is non-toxic and non-irritating when used in appropriate concentrations. Emphasizes the importance of impurity testing. 
• Read the study

2. Evaluation of Safety and Effectiveness of Novel Glycerin Compounds for Atopic Dermatitis 

• Focus: Examines glycerin-based compounds for treating atopic dermatitis. 
• Key Findings: Demonstrates glycerin's effectiveness in improving skin hydration and reducing irritation, with recommendations for further research. 
• [Read the study](https://www.jaad.org/article/S0190-9622(24)01875-9/abstract)

3. A Double-Blind Study Comparing the Effect of Glycerin and Urea on Dry, Eczematous Skin in Atopic Patients 

• Focus: Comparison of glycerin and urea in managing dry, eczematous skin. 
• Key Findings: Glycerin effectively reduces dryness and improves skin texture, performing comparably to urea. 
• Read the study

4. Glycerin: Summary Report 

• Focus: Summarizes clinical research on glycerin's safety and dermatological applications. 
• Key Findings: Reinforces glycerin's role as a safe humectant for maintaining skin hydration. 
• Read the study

5. Effect of Glycerin on Drying Stresses in Human Stratum Corneum 

• Focus: Investigates glycerin's impact on the biomechanical properties of the skin's outer layer. 
• Key Findings: Glycerin reduces drying stresses, supporting its use in skincare to maintain hydration and elasticity. 
• [Read the study](https://www.jdsjournal.com/article/S0923-1811(10)00360-9/abstract)

Research Compilation for Aloe Barbadensis Leaf Juice

1. Aloe Barbadensis Leaf Juice in Skincare for Acne: Unraveling Its Antimicrobial Qualities 

• Focus: Explores the antimicrobial properties and safety of Aloe Barbadensis Leaf Juice for acne treatment. 
• Key Findings: Aloe Barbadensis Leaf Juice is safe and effective for various skin types, with antimicrobial benefits. 
• Read the study

2. Aloe Barbadensis Leaf Juice: Unveiling Aloe Vera's Antimicrobial Qualities for Acne Treatment and Prevention in Natural Skincare 

• Focus: Investigates the efficacy and safety of Aloe Vera in natural skincare. 
• Key Findings: Aloe Vera is safe and widely used for its antimicrobial and soothing properties. 
• Read the study

3. The Antibacterial Benefits of Aloe Barbadensis Leaf Juice in Skincare 

• Focus: Evaluates the antibacterial properties and safety of Aloe Barbadensis Leaf Juice. 
• Key Findings: Aloe Barbadensis Leaf Juice is safe and effective for improving skin health and reducing bacterial growth. 
• Read the study

4. An Evaluation of the Biological and Toxicological Properties of Aloe Barbadensis (Miller), Aloe Vera 

• Focus: Reviews the biological and toxicological properties of Aloe Vera. 
• Key Findings: Aloe Vera is safe for use in cosmetics, with no significant toxicological concerns. 
• Read the study

Research Compilation for Tocopheryl Acetate

1. Safety Assessment of Tocopherols and Tocotrienols as Used in Cosmetics 

• Focus: Reviews the safety of tocopherols, including Tocopheryl Acetate, in cosmetic formulations. 
• Key Findings: Tocopheryl Acetate is safe for use in cosmetics, with no significant adverse effects reported. 
• Read the study

2. Safety Assessment on Comedogenicity of Dermatological Products Containing d-Alpha Tocopheryl Acetate in Asian Subjects 

• Focus: Investigates the safety and comedogenicity of products containing Tocopheryl Acetate. 
• Key Findings: Tocopheryl Acetate is safe and non-comedogenic, suitable for acne-prone skin. 
• Read the study

3. Disposition and Metabolism of Topically Administered α-Tocopherol Acetate 

• Focus: Explores the metabolism and safety of Tocopheryl Acetate in topical applications. 
• Key Findings: Tocopheryl Acetate is safe and well-tolerated, with no significant hazards identified. 
• Read the study

4. Patch Testing with Tocopherol and Tocopherol Acetate: The North American Contact Dermatitis Group Experience (2001–2016) 

• Focus: Analyzes patch test data for Tocopheryl Acetate to assess its safety. 
• Key Findings: Tocopheryl Acetate is generally safe, with rare cases of contact dermatitis reported. 
• Read the study

Research Compilation for Totarol 

1. Mini Hyaluronic Acid-Modified Nanoliposomes for Topical Co-Delivery of Paeonol, Totarol, and Ergothioneine 

• Focus: Explores the use of Totarol in combination with other ingredients for acne treatment. 
• Key Findings: Totarol is safe and effective, with superior skin penetration and antimicrobial properties. 
• Read the study

2. Evaluation of Totarol for Promoting Open Wound Healing in Dogs 

• Focus: Investigates the antimicrobial properties and safety of Totarol in wound healing. 
• Key Findings: Totarol is safe and effective for skin care, with no significant adverse effects reported. 
• Read the study

Research Compilation for Hamamelis Virginiana L.

1. Hamamelis Virginiana L. in Skin Care: A Review of Its Pharmacological Properties and Cosmetological Applications 

• Focus: Reviews the pharmacological properties and cosmetic applications of witch hazel. 
• Key Findings: Witch hazel is safe for use in skincare, with minimal side effects such as occasional skin irritation. 
• Read the study

2. Comparative Analysis of Polyphenol-Rich Extracts from Hamamelis Virginiana Leaves and Bark 

• Focus: Evaluates the antioxidant and anti-inflammatory effects of witch hazel extracts. 
• Key Findings: Witch hazel is effective in reducing oxidative stress and inflammation, with a strong safety profile for long-term use. 
• Read the study

3. The Protective Effect of Hamamelis Virginiana Stem and Leaf Extract on Fine Dust-Induced Damage on Human Keratinocytes 

• Focus: Investigates the protective effects of witch hazel against environmental damage. 
• Key Findings: Witch hazel enhances skin barrier function and protects against fine dust-induced damage, with no significant safety concerns. 
• Read the study

4. Revealing the Therapeutic Potential: Investigating the Impact of a Novel Witch Hazel Formula on Anti-Inflammation and Antioxidation 

• Focus: Explores the anti-inflammatory and antioxidant properties of a novel witch hazel formula. 
• Key Findings: Demonstrates the safety and efficacy of witch hazel in enhancing skin health and reducing inflammation. 
• Read the study

Research Compilation for Xanthan Gum

1. Xanthan Gum: Applications, Challenges, and Advantages of This Asset of Biotechnological Origin 

• Focus: Highlights the properties and applications of xanthan gum in cosmetics and skincare. 
• Key Findings: Xanthan gum is considered safe for use in skincare formulations, with its safety depending on the quality and source of the ingredient. 
• Read the study

2. The Potential Emulsions of Xanthan Gum and Daucus Carota Macerated Oil in Functional Textiles for Skincare Applications 

• Focus: Investigates xanthan gum's role in skincare textiles for hydration and comfort. 
• Key Findings: Xanthan gum contributes to skin hydration and comfort, making it a valuable ingredient in skincare applications. 
• Read the study

3. Bioactivity and Dermal Toxicity of Skincare Textiles 

• Focus: Examines the dermal toxicity and antibacterial properties of xanthan gum in skincare textiles. 
• Key Findings: Xanthan gum is safe for dermal applications and enhances antibacterial effectiveness when combined with other systems. 
• Read the study

4. Safety Assessment of Microbial Polysaccharide Gums as Used in Cosmetics 

• Focus: Comprehensive safety assessment of microbial polysaccharide gums, including xanthan gum. 
• Key Findings: Xanthan gum is safe for use in cosmetics, functioning as a skin protectant and stabilizer. 
• Read the study

5. Xanthan Gum in Drug Release 

• Focus: Explores xanthan gum's applications in drug delivery and its safety profile. 
• Key Findings: Approved by the FDA as a safe polymer, xanthan gum is widely used in various industries, including cosmetics, for its biocompatibility. 
• Read the study

Research Compilation for Phenoxyethanol

1. Safety Review of Phenoxyethanol When Used as a Preservative in Cosmetics 

• Focus: Comprehensive review of phenoxyethanol's safety as a preservative in cosmetic products. 
• Key Findings: Phenoxyethanol is well-tolerated and safe for use in cosmetics, even on injured skin, when used within recommended concentrations. 
• Read the study

2. Opinion of the Scientific Committee on Consumer Safety (SCCS) on Phenoxyethanol in Cosmetic Products 

• Focus: Evaluates the safety of phenoxyethanol based on data submitted by Cosmetics Europe. 
• Key Findings: Confirms the safety of phenoxyethanol as a preservative in cosmetics, supporting its continued use. 
• Read the study

3. Phenoxyethanol, Reproduction, and Development: Additional Studies Are Needed 

• Focus: Discusses the need for further studies on phenoxyethanol's effects on reproduction and development. 
• Key Findings: While generally safe, additional research is recommended to address specific concerns. 
• Read the study

4. Dermal Penetration of 2-Phenoxyethanol in Humans: In Vivo Metabolism and Toxicokinetics 

• Focus: Investigates the absorption and metabolism of phenoxyethanol in human skin. 
• Key Findings: Phenoxyethanol is absorbed and metabolized safely, with no significant toxic effects observed. 
• Read the study

5. Fragrance Material Review on 2-Phenoxyethanol 

• Focus: Reviews the dermatological safety of phenoxyethanol when used as a fragrance ingredient. 
• Key Findings: Phenoxyethanol is safe for use in cosmetics, with minimal risk of irritation or sensitization. 
• Read the study

Research Compilation for Ethylhexylglycerin

1. Ethylhexylglycerin: A Low-Risk, but Highly Relevant, Sensitizer in 'Hypo-Allergenic' Cosmetics 

• Focus: Evaluates the sensitization potential of ethylhexylglycerin in cosmetics. 
• Key Findings: Ethylhexylglycerin is generally safe but may act as a low-risk sensitizer in some individuals. Further studies on concentration levels are recommended. 
• Read the study

2. Patch Testing to Ethylhexylglycerin: The North American Contact Dermatitis Group Experience (2013–2018) 

• Focus: Reviews patch testing results for ethylhexylglycerin in cosmetic products. 
• Key Findings: Ethylhexylglycerin is safe for most users, with rare cases of contact dermatitis reported. Manufacturers are encouraged to continue monitoring its use. 
• Read the study

3. Ethylhexylglycerin—A Contact Allergen in Cosmetic Products 

• Focus: Investigates cases of contact allergy linked to ethylhexylglycerin in cosmetics. 
• Key Findings: While rare, ethylhexylglycerin can cause contact allergies in sensitive individuals, highlighting the need for awareness in hypoallergenic formulations. 
• Read the study

Research Compilation for Alcohol

1. Safety Evaluation of Topical Applications of Ethanol on the Skin and Inside the Oral Cavity 

• Focus: Reviews the safety of ethanol (alcohol) in topical applications. 
• Key Findings: Ethanol is generally safe for use on intact skin but is not recommended for use on abraded or lacerated skin due to potential irritation. 
• Read the study

2. Is Alcohol Safe in Skincare? 

• Focus: Explores the effects of alcohol in skincare formulations. 
• Key Findings: Alcohol is safe in skincare when used in appropriate concentrations, though excessive use may disrupt the skin's moisture barrier. 
• Read the study

3. Assessing the Adverse Effects and Safety Concerns Related to Cosmetic and Skincare Products 

• Focus: Systematic review of safety concerns in cosmetic products, including alcohol. 
• Key Findings: Alcohol is safe for most users, but excessive or prolonged use may lead to dryness or irritation in sensitive individuals. 
• Read the study

4. Skin Safety and Health Prevention: An Overview of Chemicals in Cosmetic Products 

• Focus: Examines the safety of various chemicals, including alcohol, in cosmetics. 
• Key Findings: Alcohol is a common ingredient in cosmetics and is generally safe, though it may act as a skin sensitizer in rare cases. 
• Read the study

5. How Irritant is Alcohol? 

• Focus: Investigates the irritant potential of alcohol in skincare. 
• Key Findings: Alcohol can cause mild irritation and reduce skin hydration with repeated use, but it is safe when used in moderation. 
• Read the study

Research Compilation for Sodium Benzoate 

1. Final Report on the Safety Assessment of Benzyl Alcohol, Benzoic Acid, and Sodium Benzoate 

• Focus: Reviews the safety of Sodium Benzoate as a preservative in cosmetics. 
• Key Findings: Sodium Benzoate is safe for use in cosmetics when used within recommended concentrations. 
• Read the study

2. Skin Safety and Health Prevention: An Overview of Chemicals in Cosmetic Products 

• Focus: Explores the safety of various chemicals, including Sodium Benzoate, in cosmetic products. 
• Key Findings: Sodium Benzoate is commonly used in rinse-off products and is considered safe for skin. 
• Read the study

3. Sodium Benzoate—Harmfulness and Potential Use in Therapies for Disorders Related to the Nervous System 

• Focus: Investigates the safety and potential effects of Sodium Benzoate. 
• Key Findings: Sodium Benzoate is officially regarded as safe, though rare cases of skin reactions have been observed. 
• Read the study

4. Sodium Benzoate-Induced Repeated Episodes of Acute Urticaria/Angio-Oedema 

• Focus: Examines the potential for Sodium Benzoate to cause skin reactions. 
• Key Findings: Rare cases of urticaria and angio-oedema have been linked to Sodium Benzoate, though it is generally safe. 
• Read the study

Research Compilation for Potassium Sorbate

1. Allergic Contact Dermatitis from Potassium Sorbate and Sorbic Acid in Topical Pharmaceuticals and Medical Devices

• Focus: Investigates the potential for Potassium Sorbate to cause allergic contact dermatitis when used in topical products.
• Key Findings: Potassium Sorbate is considered a rare skin sensitizer. While generally safe, it can cause irritation or allergic reactions in individuals with compromised skin barriers.
• Read the study

2. Scientific Opinion on the Re-evaluation of Sorbic Acid (E 200), Potassium Sorbate (E 202) and Calcium Sorbate (E 203) as Food Additives

• Focus: Reviews the overall safety of Potassium Sorbate, with findings applicable to its use in cosmetics.
• Key Findings: The study found no evidence of genotoxic activity for Potassium Sorbate, supporting its safety and efficacy as a preservative.
• Read the study

3. Skin Safety and Health Prevention: An Overview of Chemicals in Cosmetic Products

• Focus: Provides an overview of common chemicals used in cosmetic products, including the preservative Potassium Sorbate.
• Key Findings: Potassium Sorbate is frequently used as a preservative in cosmetics and is considered safe for this application, though it has been noted as a potential skin sensitizer.
• Read the study

4. Scientific Opinion on the Safety and Efficacy of Potassium Sorbate as a Silage Additive

• Focus: Assesses the safety of Potassium Sorbate, noting its effects upon contact.
• Key Findings: This opinion identifies Potassium Sorbate as a skin and eye irritant but does not regard it as a skin sensitizer, confirming its low risk for causing allergic reactions.
• Read the study

Research Compilation for Maltodextrin

1. Anti-Aging Effects of Monomethylsilanetriol and Maltodextrin-Stabilized Orthosilicic Acid on Nails, Skin, and Hair 

• Focus: Explores the anti-aging benefits and safety of Maltodextrin-stabilized orthosilicic acid in skincare. 
• Key Findings: Maltodextrin is safe and effective for improving skin parameters, with no adverse effects reported. 
• Read the study

2. A Review on Applications of Maltodextrin in the Pharmaceutical Industry 

• Focus: Reviews the safety and applications of Maltodextrin, including its use in cosmetics. 
• Key Findings: Maltodextrin is safe, non-toxic, and widely used as a stabilizer and bulking agent in formulations. 
• Read the study

3. Safety Assessment of Plant Polysaccharide Gums as Used in Cosmetics 

• Focus: Evaluates the safety of plant-derived polysaccharides, including Maltodextrin, in cosmetic formulations. 
• Key Findings: Maltodextrin is safe for use in cosmetics, with no significant adverse effects observed. 
• Read the study

Research Compilation for Syringa Vulgaris Extracts 

1. Chemical Profile, Cytotoxic Activity, and Oxidative Stress Reduction of Different Syringa Vulgaris Extracts 

• Focus: Investigates the chemical composition and safety of Syringa Vulgaris extracts, including their cytotoxic and antioxidant properties. 
• Key Findings: Syringa Vulgaris extracts are safe and effective in reducing oxidative stress, with no significant cytotoxic effects observed. 
• Read the study

2. Syringa Vulgaris: Applications in Wound Healing and Photoprotection 

• Focus: Explores the wound-healing and photoprotective properties of Syringa Vulgaris cell cultures. 
• Key Findings: Syringa Vulgaris cell cultures are safe and beneficial for skin health, accelerating wound healing and providing photoprotection. 
• Read the study

This product is for external use only and is not intended to be ingested. Avoid contact with eyes. In case of irritation, discontinue use. Keep out of reach of children. Store in a cool, dry place.

• Moisturizes & Hydrates
• Targets Fine Lines