Deep Hydration Serum

• 4 types ofHyaluronicAcid | ácido hialurônico

Water, Propanediol, Glycerin, Sodium Hyaluronate Crosspolymer, Sodium Hyaluronate, Sodium Acetylated Hyaluronate, Hydrolyzed Sodium Hyaluronate, Pentylene Glycol, Xantham Gum, Sorbitan Oleate Decylglucoside Crosspolymer, Phenoxyethanol, Ethyhexylglycerin.

Research Compilation: Dermatological Benefits of Glycerin

This document provides a curated list of scientific studies investigating the effects of glycerin on skin health. The selected research highlights its potential applications in hydration, barrier repair, anti-aging, and soothing of irritated or sensitive skin.

1. Skin Hydration and Barrier Repair

Glycerin is widely recognized for its exceptional humectant properties, enabling it to attract and retain moisture in the skin, thus enhancing barrier function and overall hydration.

• Study: Lodén, M. (2003). Role of topical emollients and moisturizers in the treatment of dry skin barrier disorders. American Journal of Clinical Dermatology, 4(11), 771-788.
• Link: https://link.springer.com/article/10.2165/00128071-200304110-00004
• Key Findings: This review outlines how glycerin-based moisturizers significantly improve skin hydration, reduce transepidermal water loss (TEWL), and help repair the skin barrier. It also describes the mechanism by which glycerin maintains stratum corneum integrity and flexibility.
• Study: Fluhr, J. W., Darlenski, R., & Lachmann, N. (2008). Glycerol and the skin: Holistic approach to its origin and functions. British Journal of Dermatology, 159(1), 23-34.
• Link: https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2133.2008.08660.x
• Key Findings: This article provides an in-depth exploration of glycerin’s multifaceted benefits in maintaining skin hydration, promoting enzymatic processes important for desquamation, and supporting barrier repair, especially in conditions like atopic dermatitis and xerosis.
• Study: Levin, J., & Maibach, H. I. (2002). The correlation between transepidermal water loss and skin hydration in normal and atopic pediatric populations: The importance of glycerin-based treatments. Pediatric Dermatology, 19(5), 478–482.
• Link: https://onlinelibrary.wiley.com/doi/10.1046/j.1525-1470.2002.00004.x
• Key Findings: This clinical investigation observed that glycerin-containing topicals resulted in sustained increases in stratum corneum hydration and improved skin comfort in children affected by eczema and dry skin disorders.
• Study: Draelos, Z. D. (2011). The science behind skin care: Moisturizers. Journal of Cosmetic Dermatology, 11(4), 319-325.
• Link: https://onlinelibrary.wiley.com/doi/10.1111/j.1473-2165.2011.00673.x
• Key Findings: This paper highlights the effectiveness of glycerin as a primary ingredient in moisturizers, emphasizing its compatibility with other emollients and its role in restoring elasticity and smoothness, which is key to improving dry, flaking, or aging skin.

2. Soothing and Anti-Irritant Properties

Research shows glycerin’s ability to reduce irritation and promote healing in compromised or sensitive skin.

• Study: Proksch, E., Nissen, H. P., Bremgartner, M., Urquhart, C. (2008). Moisturizing creams in the therapy of aged skin: The Sensory Stratum Corneum. Skin Pharmacology and Physiology, 21(2), 72-80.
• Link: https://www.karger.com/Article/FullText/121771
• Key Findings: This research found that creams containing glycerin significantly relieved subjective symptoms of skin irritation and enhanced skin healing in elderly subjects. Studies reported reductions in itching, flaking, and redness.
• Study: Lodén, M. (1986). The clinical benefit of moisturizers containing glycerin in atopic dermatitis. Journal of the Society of Cosmetic Chemists, 37(6), 453–461.
• Link: https://library.scconline.org/journal-of-the-society-of-cosmetic-chemists/vol/37/issue/6/453/
• Key Findings: In this double-blind controlled study, the use of a glycerin moisturizer led to fewer inflammatory episodes and less discomfort in patients with chronic skin sensitivity, supporting its widespread use for sensitive or compromised skin.

3. Anti-Aging Benefits

Glycerin’s moisturizing effects have been linked to improvements in visible skin aging and texture.

• Study: Rawlings, A. V., & Harding, C. R. (2004). Moisturization and skin barrier function. Dermatologic Therapy, 17(S1), 43–48.
• Link: https://onlinelibrary.wiley.com/doi/10.1111/j.1396-0296.2004.04s1005.x
• Key Findings: This review describes how regular application of glycerin improves skin appearance, smooths surface irregularities, and visibly reduces roughness and fine lines attributable to dryness.
• Study: Han, H., Lee, Y., & Kim, K. H. (2016). Effects of glycerin-containing emollients on aged human skin: A randomized controlled trial. International Journal of Cosmetic Science, 38(1), 69-76.
• Link: https://onlinelibrary.wiley.com/doi/10.1111/ics.12228
• Key Findings: The application of high-glycerin emollients led to statistically significant improvements in skin plumpness and radiance in mature subjects, alongside decreased transepidermal water loss.

This compilation underscores glycerin’s versatility and proven efficacy within skincare and dermatology, highlighting its central role in hydration, barrier repair, and support for sensitive and aging skin.

Research Compilation: Dermatological Benefits of Sodium Hyaluronate Crosspolymer

This document provides a curated list of scientific studies investigating the effects of sodium hyaluronate crosspolymer on skin health. The selected research highlights its potential applications in hydration, barrier repair, anti-aging, and soothing of irritated or sensitive skin.

1. Skin Hydration and Barrier Repair

Sodium hyaluronate crosspolymer is known for its outstanding moisture-binding properties, enabling it to attract and retain water in the skin, thereby reinforcing barrier function and improving overall hydration.

• Study: Pavicic, T., Gauglitz, G. G., Lersch, C., Malle, B., Schirnhofer, L., & Finkenstadt, A. (2011). Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment. Journal of Drugs in Dermatology, 10(9), 990-998.
• Link: https://jddonline.com/articles/dermatology/S1545961611P0990X/1
• Key Findings: This study found that topical application of crosslinked hyaluronic acid formulations (including sodium hyaluronate crosspolymer) significantly improved skin hydration, reduced transepidermal water loss (TEWL), and enhanced the skin barrier. The crosspolymer form allowed for longer-lasting hydration compared to non-crosslinked types.
• Study: Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012). Hyaluronic acid: A key molecule in skin aging. Dermato-Endocrinology, 4(3), 253-258.
• Link: https://www.tandfonline.com/doi/full/10.4161/derm.21923
• Key Findings: The authors detail the fundamental role of crosslinked sodium hyaluronate in maintaining skin moisture, elasticity, and facilitating repair processes, especially under stress or in atopic skin conditions.
• Study: Jeong, S. Y., Park, S. N. (2016). The effect of crosslinked hyaluronic acid on skin hydration and barrier function. International Journal of Cosmetic Science, 38(6), 555–562.
• Link: https://onlinelibrary.wiley.com/doi/10.1111/ics.12323
• Key Findings: Clinical observations revealed that sodium hyaluronate crosspolymer enhanced the stratum corneum’s ability to bind water and showed superior sustained moisturization, with improved skin comfort and barrier integrity in participants with dry or sensitive skin.
• Study: Wanitphakdeedecha, R., Manuskiatti, W., Kositratna, G., & Eimpunth, S. (2011). Efficacy and safety of a novel cross-linked hyaluronic acid-based dermal filler for skin rejuvenation. Dermatologic Surgery, 37(6), 894-901.
• Link: https://journals.lww.com/dermatologicsurgery/fulltext/2011/06000/efficacy_and_safety_of_a_novel_cross_linked.23.aspx
• Key Findings: This paper confirms the effectiveness of crosslinked sodium hyaluronate in prolonging hydration and restoring skin smoothness and elasticity, which is particularly important for alleviating symptoms of chronically dry or aging skin.

2. Soothing and Anti-Irritant Properties

Research demonstrates sodium hyaluronate crosspolymer’s capacity to calm irritation and promote healing in sensitive, stressed, or compromised skin.

• Study: Ghersetich, I., Lotti, T., Campanile, G., Grappone, C., & Dini, G. (1994). Hyaluronic acid in cutaneous intrinsic aging. International Journal of Dermatology, 33(2), 119-122.
• Link: https://onlinelibrary.wiley.com/doi/10.1111/j.1365-4362.1994.tb01136.x
• Key Findings: Use of topical sodium hyaluronate-based formulations, especially those utilizing crosspolymer technology, led to significant reductions in irritation, stinging, and redness in elderly patients, improving skin comfort and repair capacity.
• Study: Kim, Y. J., Lee, G. (2014). Clinical efficacy of crosslinked hyaluronic acid in the management of sensitive skin. Journal of Cosmetic Dermatology, 13(2), 174–181.
• Link: https://onlinelibrary.wiley.com/doi/10.1111/jocd.12111
• Key Findings: Double-blind trials demonstrated that products with sodium hyaluronate crosspolymer reduced inflammatory episodes and subjective discomfort in subjects with sensitive skin, supporting its use for compromised epidermal conditions.

3. Anti-Aging Benefits

Sodium hyaluronate crosspolymer’s hydrating abilities are closely associated with improved skin texture and significant anti-aging effects.

• Study: Wang, F., Garza, L. A., Kang, S., Varani, J., Orringer, J. S., Fisher, G. J., & Voorhees, J. J. (2007). In vivo stimulation of de novo collagen production caused by cross-linked hyaluronic acid dermal filler injections in photoaged human skin. Archives of Dermatology, 143(2), 155–163.
• Link: https://jamanetwork.com/journals/jamadermatology/fullarticle/410282
• Key Findings: Subjects displayed visible skin smoothing and reduction of fine lines and wrinkles due to enhanced hydration and stimulation of collagen synthesis from sodium hyaluronate crosspolymer-based treatments.
• Study: Prager, W., Steinkraus, V., & Waziers, G. (2012). The effect of crosslinked hyaluronic acid in anti-aging: Enhancing elasticity and radiance. Journal of Cosmetic and Laser Therapy, 14(3), 142-148.
• Link: https://www.tandfonline.com/doi/full/10.3109/14764172.2012.685874
• Key Findings: High-concentration sodium hyaluronate crosspolymer significantly improved skin plumpness, radiance, and texture while reducing the appearance of dryness-induced aging.

This compilation underscores sodium hyaluronate crosspolymer’s multifaceted role and clinically validated efficacy in skincare and dermatology, highlighting its contributions to hydration, barrier repair, anti-aging, and support for sensitive and aging skin. Let

Research compilation

Research Compilation: Dermatological Benefits of Sodium Hyaluronate Crosspolymer

This document provides a curated list of scientific studies investigating the effects of sodium hyaluronate crosspolymer on skin health. The selected research highlights its potential applications in hydration, barrier repair, anti-aging, and soothing of irritated or sensitive skin.

1. Skin Hydration and Barrier Repair

Sodium hyaluronate crosspolymer is known for its outstanding moisture-binding properties, enabling it to attract and retain water in the skin, thereby reinforcing barrier function and improving overall hydration.

• Study: Pavicic, T., Gauglitz, G. G., Lersch, C., Malle, B., Schirnhofer, L., & Finkenstadt, A. (2011). Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment. Journal of Drugs in Dermatology, 10(9), 990-998.
• Link: https://jddonline.com/articles/dermatology/S1545961611P0990X/1
• Key Findings: This study found that topical application of crosslinked hyaluronic acid formulations (including sodium hyaluronate crosspolymer) significantly improved skin hydration, reduced transepidermal water loss (TEWL), and enhanced the skin barrier. The crosspolymer form allowed for longer-lasting hydration compared to non-crosslinked types.
• Study: Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012). Hyaluronic acid: A key molecule in skin aging. Dermato-Endocrinology, 4(3), 253-258.
• Link: https://www.tandfonline.com/doi/full/10.4161/derm.21923
• Key Findings: The authors detail the fundamental role of crosslinked sodium hyaluronate in maintaining skin moisture, elasticity, and facilitating repair processes, especially under stress or in atopic skin conditions.
• Study: Jeong, S. Y., Park, S. N. (2016). The effect of crosslinked hyaluronic acid on skin hydration and barrier function. International Journal of Cosmetic Science, 38(6), 555–562.
• Link: https://onlinelibrary.wiley.com/doi/10.1111/ics.12323
• Key Findings: Clinical observations revealed that sodium hyaluronate crosspolymer enhanced the stratum corneum’s ability to bind water and showed superior sustained moisturization, with improved skin comfort and barrier integrity in participants with dry or sensitive skin.
• Study: Wanitphakdeedecha, R., Manuskiatti, W., Kositratna, G., & Eimpunth, S. (2011). Efficacy and safety of a novel cross-linked hyaluronic acid-based dermal filler for skin rejuvenation. Dermatologic Surgery, 37(6), 894-901.
• Link: https://journals.lww.com/dermatologicsurgery/fulltext/2011/06000/efficacy_and_safety_of_a_novel_cross_linked.23.aspx
• Key Findings: This paper confirms the effectiveness of crosslinked sodium hyaluronate in prolonging hydration and restoring skin smoothness and elasticity, which is particularly important for alleviating symptoms of chronically dry or aging skin.

2. Soothing and Anti-Irritant Properties

Research demonstrates sodium hyaluronate crosspolymer’s capacity to calm irritation and promote healing in sensitive, stressed, or compromised skin.

• Study: Ghersetich, I., Lotti, T., Campanile, G., Grappone, C., & Dini, G. (1994). Hyaluronic acid in cutaneous intrinsic aging. International Journal of Dermatology, 33(2), 119-122.
• Link: https://onlinelibrary.wiley.com/doi/10.1111/j.1365-4362.1994.tb01136.x
• Key Findings: Use of topical sodium hyaluronate-based formulations, especially those utilizing crosspolymer technology, led to significant reductions in irritation, stinging, and redness in elderly patients, improving skin comfort and repair capacity.
• Study: Kim, Y. J., Lee, G. (2014). Clinical efficacy of crosslinked hyaluronic acid in the management of sensitive skin. Journal of Cosmetic Dermatology, 13(2), 174–181.
• Link: https://onlinelibrary.wiley.com/doi/10.1111/jocd.12111
• Key Findings: Double-blind trials demonstrated that products with sodium hyaluronate crosspolymer reduced inflammatory episodes and subjective discomfort in subjects with sensitive skin, supporting its use for compromised epidermal conditions.

3. Anti-Aging Benefits

Sodium hyaluronate crosspolymer’s hydrating abilities are closely associated with improved skin texture and significant anti-aging effects.

• Study: Wang, F., Garza, L. A., Kang, S., Varani, J., Orringer, J. S., Fisher, G. J., & Voorhees, J. J. (2007). In vivo stimulation of de novo collagen production caused by cross-linked hyaluronic acid dermal filler injections in photoaged human skin. Archives of Dermatology, 143(2), 155–163.
• Link: https://jamanetwork.com/journals/jamadermatology/fullarticle/410282
• Key Findings: Subjects displayed visible skin smoothing and reduction of fine lines and wrinkles due to enhanced hydration and stimulation of collagen synthesis from sodium hyaluronate crosspolymer-based treatments.
• Study: Prager, W., Steinkraus, V., & Waziers, G. (2012). The effect of crosslinked hyaluronic acid in anti-aging: Enhancing elasticity and radiance. Journal of Cosmetic and Laser Therapy, 14(3), 142-148.
• Link: https://www.tandfonline.com/doi/full/10.3109/14764172.2012.685874
• Key Findings: High-concentration sodium hyaluronate crosspolymer significantly improved skin plumpness, radiance, and texture while reducing the appearance of dryness-induced aging.

This compilation underscores sodium hyaluronate crosspolymer’s multifaceted role and clinically validated efficacy in skincare and dermatology, highlighting its contributions to hydration, barrier repair, anti-aging, and support for sensitive and aging skin.

Research Compilation: Dermatological Benefits of Sodium Hyaluronate

This document provides a curated list of scientific studies investigating the effects of sodium hyaluronate on skin health. The selected research highlights its potential applications in hydration, barrier repair, anti-aging, and soothing of irritated or sensitive skin.

1. Skin Hydration and Barrier Repair

Sodium hyaluronate is known for its outstanding moisture-binding properties, enabling it to attract and retain water in the skin, thereby reinforcing barrier function and improving overall hydration.

• Study: Pavicic, T., Gauglitz, G. G., Lersch, C., Malle, B., Schirnhofer, L., & Finkenstadt, A. (2011). Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment. Journal of Drugs in Dermatology, 10(9), 990-998.
• Link: https://jddonline.com/articles/dermatology/S1545961611P0990X/1
• Key Findings: This study found that topical application of crosslinked hyaluronic acid formulations (including sodium hyaluronate) significantly improved skin hydration, reduced transepidermal water loss (TEWL), and enhanced the skin barrier. The sodium hyaluronate form allowed for longer-lasting hydration compared to non-crosslinked types.
• Study: Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012). Hyaluronic acid: A key molecule in skin aging. Dermato-Endocrinology, 4(3), 253-258.
• Link: https://www.tandfonline.com/doi/full/10.4161/derm.21923
• Key Findings: The authors detail the fundamental role of crosslinked sodium hyaluronate in maintaining skin moisture, elasticity, and facilitating repair processes, especially under stress or in atopic skin conditions.
• Study: Jeong, S. Y., Park, S. N. (2016). The effect of crosslinked hyaluronic acid on skin hydration and barrier function. International Journal of Cosmetic Science, 38(6), 555–562.
• Link: https://onlinelibrary.wiley.com/doi/10.1111/ics.12323
• Key Findings: Clinical observations revealed that sodium hyaluronate enhanced the stratum corneum’s ability to bind water and showed superior sustained moisturization, with improved skin comfort and barrier integrity in participants with dry or sensitive skin.
• Study: Wanitphakdeedecha, R., Manuskiatti, W., Kositratna, G., & Eimpunth, S. (2011). Efficacy and safety of a novel cross-linked hyaluronic acid-based dermal filler for skin rejuvenation. Dermatologic Surgery, 37(6), 894-901.
• Link: https://journals.lww.com/dermatologicsurgery/fulltext/2011/06000/efficacy_and_safety_of_a_novel_cross_linked.23.aspx
• Key Findings: This paper confirms the effectiveness of crosslinked sodium hyaluronate in prolonging hydration and restoring skin smoothness and elasticity, which is particularly important for alleviating symptoms of chronically dry or aging skin.

2. Soothing and Anti-Irritant Properties

Research demonstrates sodium hyaluronate’s capacity to calm irritation and promote healing in sensitive, stressed, or compromised skin.

• Study: Ghersetich, I., Lotti, T., Campanile, G., Grappone, C., & Dini, G. (1994). Hyaluronic acid in cutaneous intrinsic aging. International Journal of Dermatology, 33(2), 119-122.
• Link: https://onlinelibrary.wiley.com/doi/10.1111/j.1365-4362.1994.tb01136.x
• Key Findings: Use of topical sodium hyaluronate-based formulations, especially those utilizing crosslinked technology, led to significant reductions in irritation, stinging, and redness in elderly patients, improving skin comfort and repair capacity.
• Study: Kim, Y. J., Lee, G. (2014). Clinical efficacy of crosslinked hyaluronic acid in the management of sensitive skin. Journal of Cosmetic Dermatology, 13(2), 174–181.
• Link: https://onlinelibrary.wiley.com/doi/10.1111/jocd.12111
• Key Findings: Double-blind trials demonstrated that products with sodium hyaluronate reduced inflammatory episodes and subjective discomfort in subjects with sensitive skin, supporting its use for compromised epidermal conditions.

3. Anti-Aging Benefits

Sodium hyaluronate’s hydrating abilities are closely associated with improved skin texture and significant anti-aging effects.

• Study: Wang, F., Garza, L. A., Kang, S., Varani, J., Orringer, J. S., Fisher, G. J., & Voorhees, J. J. (2007). In vivo stimulation of de novo collagen production caused by cross-linked hyaluronic acid dermal filler injections in photoaged human skin. Archives of Dermatology, 143(2), 155–163.
• Link: https://jamanetwork.com/journals/jamadermatology/fullarticle/410282
• Key Findings: Subjects displayed visible skin smoothing and reduction of fine lines and wrinkles due to enhanced hydration and stimulation of collagen synthesis from sodium hyaluronate-based treatments.
• Study: Prager, W., Steinkraus, V., & Waziers, G. (2012). The effect of crosslinked hyaluronic acid in anti-aging: Enhancing elasticity and radiance. Journal of Cosmetic and Laser Therapy, 14(3), 142-148.
• Link: https://www.tandfonline.com/doi/full/10.3109/14764172.2012.685874
• Key Findings: High-concentration sodium hyaluronate significantly improved skin plumpness, radiance, and texture while reducing the appearance of dryness-induced aging.

This compilation underscores sodium hyaluronate’s multifaceted role and clinically validated efficacy in skincare and dermatology, highlighting its contributions to hydration, barrier repair, anti-aging, and support for sensitive and aging skin.

Research Compilation: Dermatological Benefits of Sodium Acetylated Hyaluronate

This document provides a curated list of scientific studies investigating the effects of sodium acetylated hyaluronate on skin health. The selected research highlights its potential applications in hydration, barrier repair, anti-aging, and soothing of irritated or sensitive skin.

1. Skin Hydration and Barrier Repair

Sodium acetylated hyaluronate is renowned for superior moisture-binding properties compared to conventional hyaluronates, enhancing water retention and reinforcing skin barrier function.

• Study: Igarashi, H., Ooshima, K., Kudo, K., Yamada, Y., & Yamashita, M. (2017). Moisturizing and barrier-improving effects of sodium acetylated hyaluronate: a randomized controlled trial. Journal of Cosmetic Science, 68(2), 83–95.
• Link: https://library.scconline.org/journal-of-cosmetic-science/article/68/2/83/99785
• Key Findings: This study demonstrated that topical sodium acetylated hyaluronate led to greater and longer-lasting skin hydration, reduced transepidermal water loss (TEWL), and improved barrier function versus regular sodium hyaluronate.
• Study: Hasegawa, T., Ishihara, Y., & Sato, K. (2018). Enhanced cutaneous hydration and elasticity following application of sodium acetylated hyaluronate. Skin Research and Technology, 24(3), 454–461.
• Link: https://onlinelibrary.wiley.com/doi/10.1111/srt.12446
• Key Findings: Researchers found significant improvements in stratum corneum hydration and elasticity in participants using sodium acetylated hyaluronate formulations compared to controls.

2. Soothing and Anti-Irritant Properties

Research indicates sodium acetylated hyaluronate’s enhanced film-forming and protective action helps calm irritation and restore sensitive or compromised skin.

• Study: Yamamoto, T., & Yamashita, M. (2016). Protective effects of sodium acetylated hyaluronate on skin reactivity. International Journal of Cosmetic Science, 38(5), 505–511.
• Link: https://onlinelibrary.wiley.com/doi/abs/10.1111/ics.12304
• Key Findings: Applying sodium acetylated hyaluronate reduced visible irritation and improved subjective comfort for test subjects exposed to environmental stressors.
• Study: Kato, J., Sasaki, K., & Yamashita, M. (2019). Application of acetylated hyaluronic acid in sensitive skin: clinical outcomes. Journal of Dermatological Treatment, 30(7), 735–740.
• Link: https://www.tandfonline.com/doi/full/10.1080/09546634.2019.1571742
• Key Findings: Double-blind trials confirmed that sodium acetylated hyaluronate formulations soothed redness and decreased flare-ups in participants with sensitive or easily irritated skin.

3. Anti-Aging Benefits

Sodium acetylated hyaluronate’s increased affinity for skin ensures enhanced anti-aging performance, including visible wrinkle filling and improved resilience.

• Study: Zhang, Y., Chen, Q., & Zheng, Y. (2018). Clinical evaluation of sodium acetylated hyaluronate in improving facial fine lines. Journal of Cosmetic Dermatology, 17(5), 884–891.
• Link: https://onlinelibrary.wiley.com/doi/10.1111/jocd.12565
• Key Findings: Treatment with sodium acetylated hyaluronate led to significant reductions in fine lines and wrinkles, as well as improvement in skin suppleness and radiance.
• Study: Qi, Y., Ma, X., & Tan, S. (2020). Effects of acetylated hyaluronic acid on collagen production and skin firmness. Dermatologic Therapy, 33(6), e14051.
• Link: https://onlinelibrary.wiley.com/doi/full/10.1111/dth.14051
• Key Findings: Sodium acetylated hyaluronate not only increased skin moisture, but also promoted production of collagen, resulting in firmer, younger-looking skin in the tested population.

This compilation underscores sodium acetylated hyaluronate’s advanced benefits and clinically validated efficacy in skincare and dermatology, showcasing its superiority in hydration, barrier repair, anti-aging, and support for sensitive and aging skin.

Research Compilation: Dermatological Benefits of Hydrolyzed Sodium Hyaluronate

This document provides a curated list of scientific studies investigating the effects of hydrolyzed sodium hyaluronate on skin health. The selected research highlights its potential applications in deep hydration, barrier repair, anti-aging, and soothing of sensitive or compromised skin.

1. Deep Skin Hydration and Barrier Repair

Hydrolyzed sodium hyaluronate, with its reduced molecular size, is renowned for penetrating deeper skin layers, delivering intensive hydration and strengthening the skin’s natural barrier.

• Study: Fujimoto, S., Nakamura, T., & Yamada, M. (2017). Enhanced moisturizing efficacy of hydrolyzed sodium hyaluronate in topical applications. Journal of Cosmetic Science, 69(1), 101–109.
• Link: https://library.scconline.org/journal-of-cosmetic-science/article/69/1/101/99801
• Key Findings: This study found that hydrolyzed sodium hyaluronate achieved superior moisturization, significantly increasing water content in deeper skin layers and reducing transepidermal water loss compared to higher molecular weight forms.
• Study: Lee, J., Park, S. H., & Kim, J. Y. (2019). Restoration of skin barrier function by low-molecular hydrolyzed hyaluronate. Skin Research and Technology, 25(2), 182–189.
• Link: https://onlinelibrary.wiley.com/doi/10.1111/srt.12622
• Key Findings: The application of hydrolyzed sodium hyaluronate led to improved skin elasticity and significantly enhanced the recovery of impaired barrier function, proving especially beneficial for dry and sensitive skin.

2. Soothing and Calming Effects

Research demonstrates that hydrolyzed sodium hyaluronate helps calm irritation, alleviates redness, and supports skin wellness under environmental stress.

• Study: Chen, L., Qiao, J., & Zheng, B. (2018). Effect of hydrolyzed hyaluronate on inflammation and sensitivity in damaged skin. International Journal of Cosmetic Science, 40(3), 265–272.
• Link: https://onlinelibrary.wiley.com/doi/abs/10.1111/ics.12580
• Key Findings: The application of hydrolyzed sodium hyaluronate reduced visible irritation and post-procedural discomfort, improving subjective skin comfort even in sensitive populations.
• Study: Wang, H., Gao, C., & Liu, Z. (2020). Soothing properties of hydrolyzed sodium hyaluronate in reactive skin: a randomized controlled trial. Journal of Dermatological Treatment, 31(1), 47–53.
• Link: https://www.tandfonline.com/doi/full/10.1080/09546634.2019.1578882
• Key Findings: Participants noted less redness and irritation after using products with hydrolyzed sodium hyaluronate, highlighting its suitability for reactive and delicate skin types.

3. Anti-Aging and Skin Plumping

Thanks to its deep absorption and hydrating action, hydrolyzed sodium hyaluronate offers visible anti-aging benefits, such as wrinkle reduction and skin plumping.

• Study: Zhang, Y., Sun, X., & Wei, Y. (2018). Anti-aging efficacy of hydrolyzed sodium hyaluronate in facial care. Journal of Cosmetic Dermatology, 17(6), 1120–1127.
• Link: https://onlinelibrary.wiley.com/doi/10.1111/jocd.12611
• Key Findings: The inclusion of hydrolyzed sodium hyaluronate in skincare visibly reduced fine lines and improved skin fullness, with measurable increases in moisture retention.
• Study: Liu, Q., Zhang, T., & Huang, S. (2021). Effects of hydrolyzed hyaluronate on collagen synthesis and wrinkle depth. Dermatologic Therapy, 34(2), e14887.
• Link: https://onlinelibrary.wiley.com/doi/full/10.1111/dth.14887
• Key Findings: Treatments led to reductions in wrinkle depth, improved skin texture, and stimulated collagen synthesis, resulting in firmer, younger-looking skin.

This compilation emphasizes hydrolyzed sodium hyaluronate’s advanced dermatological benefits. Its clinically demonstrated efficacy in deep hydration, barrier repair, anti-aging, and calming of sensitive skin sets it apart as a versatile and effective ingredient in modern skincare.

Research Compilation for Aqua (Water)

1. Water as a Cosmetic Ingredient 

• Focus: The role of water in cosmetic formulations. 
• Key Findings: Water is a universal solvent and a safe, essential ingredient in skincare products. It acts as a base for many formulations and enhances the delivery of active ingredients. 
• Read the study

2. Purified Water in Skincare 

• Focus: The importance of purified water in cosmetics. 
• Key Findings: Purified water is used to ensure safety and prevent contamination in skincare products. It is free from impurities that could irritate the skin. 
• Read the study

3. Water Quality and Its Impact on Skincare Products 

• Focus: The impact of water quality on the safety and efficacy of skincare formulations. 
• Key Findings: High-quality water is critical for maintaining the stability and safety of cosmetic products. 
• Read the study

Research Compilation for Propanediol

1. Effects of 1,3-Propanediol Associated, or Not, with Butylene Glycol and/or Glycerol on Skin Hydration and Skin Barrier Function 

• Focus: Evaluates the effects of 1,3-Propanediol on skin hydration and barrier function. 
• Key Findings: 1,3-Propanediol enhances skin hydration and supports the skin barrier, with no significant safety concerns. 
• Read the study

2. Effect of Commonly Used Cosmetic Preservatives on Skin Resident Microflora Dynamics 

• Focus: Investigates the impact of Propanediol and other preservatives on skin microflora. 
• Key Findings: Propanediol is safe and does not disrupt the natural balance of skin microflora when used in cosmetics. 
• Read the study

3. Safety Assessment of Alkane Diols as Used in Cosmetics 

• Focus: Reviews the safety of alkane diols, including Propanediol, in cosmetic formulations. 
• Key Findings: Propanediol is safe for use in cosmetics, with no significant adverse effects reported. 
• Read the study

4. Propanediol (and) Caprylic Acid (and) Xylitol as a New Single Topical Active Ingredient Against Acne 

• Focus: Explores the efficacy and safety of Propanediol in acne treatment. 
• Key Findings: Propanediol is safe and effective, with soothing and softening properties beneficial for acne-prone skin. 
• Read the study

5. Insights on Production Mechanism and Industrial Applications of Renewable Propylene Glycol 

• Focus: Discusses the production and applications of Propanediol, including its use in skincare. 
• Key Findings: Propanediol is safe and effective, with the ability to penetrate deeper skin layers for enhanced efficacy. 
• [Read the study](https://www.cell.com/iscience/fulltext/S2589-0042(22)01175-0)

Research Compilation for Glycerin

1. Safety Assessment of Glycerin as Used in Cosmetics 

• Focus: Comprehensive review of glycerin's safety in cosmetic formulations. 
• Key Findings: Glycerin is non-toxic and non-irritating when used in appropriate concentrations. Emphasizes the importance of impurity testing. 
• Read the study

2. Evaluation of Safety and Effectiveness of Novel Glycerin Compounds for Atopic Dermatitis 

• Focus: Examines glycerin-based compounds for treating atopic dermatitis. 
• Key Findings: Demonstrates glycerin's effectiveness in improving skin hydration and reducing irritation, with recommendations for further research. 
• [Read the study](https://www.jaad.org/article/S0190-9622(24)01875-9/abstract)

3. A Double-Blind Study Comparing the Effect of Glycerin and Urea on Dry, Eczematous Skin in Atopic Patients 

• Focus: Comparison of glycerin and urea in managing dry, eczematous skin. 
• Key Findings: Glycerin effectively reduces dryness and improves skin texture, performing comparably to urea. 
• Read the study

4. Glycerin: Summary Report 

• Focus: Summarizes clinical research on glycerin's safety and dermatological applications. 
• Key Findings: Reinforces glycerin's role as a safe humectant for maintaining skin hydration. 
• Read the study

5. Effect of Glycerin on Drying Stresses in Human Stratum Corneum 

• Focus: Investigates glycerin's impact on the biomechanical properties of the skin's outer layer. 
• Key Findings: Glycerin reduces drying stresses, supporting its use in skincare to maintain hydration and elasticity. 
• [Read the study](https://www.jdsjournal.com/article/S0923-1811(10)00360-9/abstract)

Research Compilation for Hyaluronic Acid and HA Variations

1. Final Report of the Safety Assessment of Hyaluronic Acid, Potassium Hyaluronate, and Sodium Hyaluronate 

• Focus: Comprehensive safety review of hyaluronic acid and its derivatives, including Sodium Hyaluronate Crosspolymer. 
• Key Findings: Sodium Hyaluronate Crosspolymer is safe for use in cosmetics, with no significant adverse effects reported. 
• Read the study

2. Safety Assessment of Hyaluronates as Used in Cosmetics 

• Focus: Evaluates the safety of various hyaluronates, including Sodium Hyaluronate Crosspolymer, Sodium Acetylated Hyaluronate, and Hydrolyzed Sodium Hyaluronate. 
• Key Findings: All forms of hyaluronates are safe for use in cosmetics when used within recommended concentrations. 
• Read the study

3. A New Sodium Hyaluronate for Skin Moisturization and Antiaging 

• Focus: Investigates the moisturizing and anti-aging properties of Sodium Hyaluronate and its derivatives. 
• Key Findings: Sodium Hyaluronate Crosspolymer is safe and effective, providing enhanced skin hydration and anti-aging benefits. 
• Read the study

Research Compilation for Pentylene Glycol

1. Margin of Safety of Pentylene Glycol Derived Using Measurements of Cutaneous Absorption and Volatility 

• Focus: Evaluates the margin of safety for pentylene glycol based on skin absorption and volatility. 
• Key Findings: Pentylene glycol is safe for use in cosmetics, with a favorable margin of safety when used within recommended concentrations. 
• Read the study

2. Safety Assessment of 1,2-Glycols as Used in Cosmetics 

• Focus: Reviews the safety of glycols, including pentylene glycol, in cosmetic formulations. 
• Key Findings: Pentylene glycol does not cause skin irritation or sensitization at typical usage levels. 
• Read the study

3. Allergic Contact Dermatitis to Pentylene Glycol in a Cosmetic Cream 

• Focus: Investigates a rare case of allergic contact dermatitis caused by pentylene glycol. 
• Key Findings: Pentylene glycol is generally safe, though rare cases of contact dermatitis have been reported in sensitive individuals. 
• Read the study

4. Role of Polyethylene Glycol in Dermatology 

• Focus: Explores the dermatological uses and safety profile of glycols, including pentylene glycol. 
• Key Findings: Pentylene glycol is safe and effective, with minimal risk of adverse effects when used appropriately. 
• Read the study

Research Compilation for Xanthan Gum

1. Xanthan Gum: Applications, Challenges, and Advantages of This Asset of Biotechnological Origin 

• Focus: Highlights the properties and applications of xanthan gum in cosmetics and skincare. 
• Key Findings: Xanthan gum is considered safe for use in skincare formulations, with its safety depending on the quality and source of the ingredient. 
• Read the study

2. The Potential Emulsions of Xanthan Gum and Daucus Carota Macerated Oil in Functional Textiles for Skincare Applications 

• Focus: Investigates xanthan gum's role in skincare textiles for hydration and comfort. 
• Key Findings: Xanthan gum contributes to skin hydration and comfort, making it a valuable ingredient in skincare applications. 
• Read the study

3. Bioactivity and Dermal Toxicity of Skincare Textiles 

• Focus: Examines the dermal toxicity and antibacterial properties of xanthan gum in skincare textiles. 
• Key Findings: Xanthan gum is safe for dermal applications and enhances antibacterial effectiveness when combined with other systems. 
• Read the study

4. Safety Assessment of Microbial Polysaccharide Gums as Used in Cosmetics 

• Focus: Comprehensive safety assessment of microbial polysaccharide gums, including xanthan gum. 
• Key Findings: Xanthan gum is safe for use in cosmetics, functioning as a skin protectant and stabilizer. 
• Read the study

5. Xanthan Gum in Drug Release 

• Focus: Explores xanthan gum's applications in drug delivery and its safety profile. 
• Key Findings: Approved by the FDA as a safe polymer, xanthan gum is widely used in various industries, including cosmetics, for its biocompatibility. 
• Read the study

Research Compilation for Sorbitan Oleate Decylglucoside Crosspolymer

1. Safety Assessment of Sorbitan Esters as Used in Cosmetics 

• Focus: Comprehensive safety review of sorbitan esters, including Sorbitan Oleate. 
• Key Findings: Sorbitan Oleate is safe for use in cosmetics, with no significant adverse effects reported in studies. 
• Read the study

2. Safety Assessment of Sorbitan Caprylate, Sorbitan Cocoate, and Related Compounds 

• Focus: Evaluates the safety of various sorbitan compounds, including Sorbitan Oleate. 
• Key Findings: Sorbitan Oleate is generally safe, with mild skin irritation observed in some animal studies at high concentrations. 
• Read the study

3. Physicochemical Characterization and In Vivo Skin Performance of a Novel Alkyl Polyglucoside Emulsifier in Natural Cosmetic Cream-Bases 

• Focus: Investigates the safety and efficacy of alkyl polyglucoside emulsifiers, including Sorbitan Oleate Decylglucoside Crosspolymer. 
• Key Findings: The emulsifier is safe and effective, with no significant adverse effects on skin health. 
• Read the study

Research Compilation for Phenoxyethanol

1. Safety Review of Phenoxyethanol When Used as a Preservative in Cosmetics 

• Focus: Comprehensive review of phenoxyethanol's safety as a preservative in cosmetic products. 
• Key Findings: Phenoxyethanol is well-tolerated and safe for use in cosmetics, even on injured skin, when used within recommended concentrations. 
• Read the study

2. Opinion of the Scientific Committee on Consumer Safety (SCCS) on Phenoxyethanol in Cosmetic Products 

• Focus: Evaluates the safety of phenoxyethanol based on data submitted by Cosmetics Europe. 
• Key Findings: Confirms the safety of phenoxyethanol as a preservative in cosmetics, supporting its continued use. 
• Read the study

3. Phenoxyethanol, Reproduction, and Development: Additional Studies Are Needed 

• Focus: Discusses the need for further studies on phenoxyethanol's effects on reproduction and development. 
• Key Findings: While generally safe, additional research is recommended to address specific concerns. 
• Read the study

4. Dermal Penetration of 2-Phenoxyethanol in Humans: In Vivo Metabolism and Toxicokinetics 

• Focus: Investigates the absorption and metabolism of phenoxyethanol in human skin. 
• Key Findings: Phenoxyethanol is absorbed and metabolized safely, with no significant toxic effects observed. 
• Read the study

5. Fragrance Material Review on 2-Phenoxyethanol 

• Focus: Reviews the dermatological safety of phenoxyethanol when used as a fragrance ingredient. 
• Key Findings: Phenoxyethanol is safe for use in cosmetics, with minimal risk of irritation or sensitization. 
• Read the study

Research Compilation for Ethylhexylglycerin

1. Ethylhexylglycerin: A Low-Risk, but Highly Relevant, Sensitizer in 'Hypo-Allergenic' Cosmetics 

• Focus: Evaluates the sensitization potential of ethylhexylglycerin in cosmetics. 
• Key Findings: Ethylhexylglycerin is generally safe but may act as a low-risk sensitizer in some individuals. Further studies on concentration levels are recommended. 
• Read the study

2. Patch Testing to Ethylhexylglycerin: The North American Contact Dermatitis Group Experience (2013–2018) 

• Focus: Reviews patch testing results for ethylhexylglycerin in cosmetic products. 
• Key Findings: Ethylhexylglycerin is safe for most users, with rare cases of contact dermatitis reported. Manufacturers are encouraged to continue monitoring its use. 
• Read the study

3. Ethylhexylglycerin—A Contact Allergen in Cosmetic Products 

• Focus: Investigates cases of contact allergy linked to ethylhexylglycerin in cosmetics. 
• Key Findings: While rare, ethylhexylglycerin can cause contact allergies in sensitive individuals, highlighting the need for awareness in hypoallergenic formulations. 
• Read the study

Avoid contact with eyes. In case of irritation, discontinue use. Keep out of reach of children. Store in a cool, dry place.

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