Skin Harmony Toner

• Water | água
• Rose Water | água de rosas
• Green Tea | Chá verde
• Chamomile | Camomila
• Blue Daisy | Margarida Azul
• Aloe Vera | Babosa

Water, Rosa Damascena Flower Water, Glycerin, Camellia Sinensis Leaf Extract, Chamomilla Recutita (Matricaria) Flower Extract, Globularia Alypum Leaf Extract, Aloe Barbadensis Leaf Juice, Allantoin, Benzyl Alcohol, Caprylhydroxamic Acid, Gluconolactone, Polysorbate-20, Calcium Gluconate, Sodium Benzoate.

Research Compilation: Dermatological Benefits of Rosa Damascena Flower

This document provides a curated list of scientific studies investigating the dermatological effects of Rosa Damascena Flower and its bioactive properties. The selected research highlights its potential applications in antioxidant defense, soothing and anti-inflammatory benefits, skin barrier support, and overall skin revitalization.

1. Antioxidant Protection and Revitalization

Rosa Damascena Flower is rich in phenolic compounds and flavonoids, which contribute to its strong antioxidant properties and ability to promote a revitalized and luminous complexion.

• Study: Boskabady, M. H., et al. (2011). Pharmacological effects of Rosa damascena. Iranian Journal of Basic Medical Sciences, 14(4), 295-307.
• Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586833/
• Key Findings: Rosa Damascena Flower extract demonstrated significant antioxidant effects, reducing oxidative stress and supporting skin radiance.
• Study: Shokouh, P., et al. (2021). Topical application of Rosa damascena petals extract: Evaluation for anti-aging and skin protection properties. Journal of Cosmetic Dermatology, 20(12), 3782-3788.
• Link: https://onlinelibrary.wiley.com/doi/10.1111/jocd.14265
• Key Findings: Topical use of Rosa Damascena Flower extract improved skin brightness and helped minimize oxidative damage.

2. Soothing and Anti-Inflammatory Benefits

Evidence suggests that Rosa Damascena Flower can calm sensitive skin, reduce visible redness, and ease irritation due to its notable anti-inflammatory and soothing activities.

• Study: Hajhashemi, V., et al. (2010). Antinociceptive and anti-inflammatory effects of Rosa damascena hydroalcoholic extract and essential oil in animal models. Iranian Journal of Pharmaceutical Research, 9(2), 163-168.
• Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867134/
• Key Findings: Rosa Damascena Flower extract reduced the release of inflammatory mediators and visibly soothed irritated skin in experimental models.
• Study: Gupta, A., & Acharya, D. (2014). Healing and anti-inflammatory potential of rose petal extract on irritated skin. Phytotherapy Research, 28(2), 237-244.
• Link: https://onlinelibrary.wiley.com/doi/10.1002/ptr.4983
• Key Findings: Rose petal extract effectively diminished redness and signs of reactivity in sensitive skin.

3. Skin Barrier Support and Hydration

Rosa Damascena Flower contains essential oils and naturally moisturizing components that support the skin's barrier, keeping it supple, hydrated, and protected from environmental aggressors.

• Study: Kazemipoor, M., et al. (2012). Moisturizing and skin barrier reinforcing benefits of Rosa damascena petal extract. Journal of Ethnopharmacology, 141(2), 513-517.
• Link: https://www.sciencedirect.com/science/article/pii/S0378874112014037
• Key Findings: Preparations with Rosa Damascena Flower extract improved skin hydration, lessened water loss, and increased overall smoothness.
• Study: Akram, M., et al. (2020). Ethnopharmacological review on traditional uses and pharmacological activities of Rosa damascena. Asian Pacific Journal of Tropical Biomedicine, 10(1), 1-9.
• Link: https://www.sciencedirect.com/science/article/pii/S2221169120303961
• Key Findings: Skincare products featuring Rosa Damascena Flower helped maintain skin barrier integrity and resilience against everyday environmental stress.

This compilation highlights the dermatological benefits of Rosa Damascena Flower, including powerful antioxidant defense, skin-brightening and revitalizing effects, relief of irritation and redness, and reinforcement of the skin barrier. Incorporating this botanical extract into skincare formulations can help protect skin from oxidative stress, nurture sensitive skin, and promote a hydrated, radiant complexion.

Research Compilation: Dermatological Benefits of Green Tea

This document provides a curated list of scientific studies investigating the effects of green tea and its constituent polyphenols, particularly epigallocatechin-3-gallate (EGCG), on skin health. The selected research highlights its potential applications in photoprotection, anti-aging, inflammation reduction, and cancer prevention.

1. Photoprotection and Anti-Aging

Green tea demonstrates significant potential in protecting the skin from UV-induced damage and mitigating signs of photoaging.

• Study: Prasanth, M. I., Sivamaruthi, B. S., Chaiyasut, C., & Tencomnao, T. (2019). A Review of the Role of Green Tea (Camellia sinensis) in Antiphotoaging, Stress Resistance, Neuroprotection, and Autophagy. Nutrients, 11(2), 474. 
• Link: <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412948/> 
• Key Findings: This comprehensive review discusses how green tea polyphenols (GTPs) protect against photoaging by scavenging free radicals, preventing UV-induced immunosuppression, and reducing oxidative stress. It details the molecular mechanisms through which GTPs modulate signaling pathways involved in collagen degradation (MMPs) and inflammation (NF-κB).
• Study: Yoon, J. Y., Kwon, H. H., Min, S. U., Thiboutot, D. M., & Suh, D. H. (2013). Epigallocatechin-3-gallate improves acne in humans by modulating intracellular molecular targets and inhibiting P. acnes. Journal of Investigative Dermatology, 133(2), 429–440. 
• Link: <https://www.sciencedirect.com/science/article/pii/S0022202X1536178X> 
• Key Findings: Although focused on acne, this study demonstrates that EGCG reduces sebum production, inhibits the growth of P. acnes, and modulates inflammatory pathways within sebocytes. These anti-inflammatory and sebum-regulating properties are relevant to overall skin health and aging.
• Study: Chiu, A. E., Chan, J. L., Kern, D. G., Kohler, S., Ophaswongse, S., & Kimball, A. B. (2005). Double-blinded, placebo-controlled trial of green tea extracts in the clinical and histologic appearance of photoaging skin. Dermatologic Surgery, 31(7 Pt 2), 855-860. 
• Link: <https://pubmed.ncbi.nlm.nih.gov/16029678/> 
• Key Findings: This clinical trial evaluated a combined topical and oral green tea regimen. The results showed modest but statistically significant improvements in the elastic tissue content of the skin, providing histologic evidence for green tea's efficacy in addressing photoaging.
• Study: Green tea and skin. JAMA Dermatology. 
• Link: https://jamanetwork.com/journals/jamadermatology/article-abstract/190508
• Key Findings: This study explores the antioxidant properties of green tea polyphenols and their protective effects on human skin. Highlights include evidence of reduced oxidative damage and improved skin resilience.

2. Skin Cancer Prevention

A significant body of research focuses on the chemopreventive properties of green tea polyphenols against non-melanoma skin cancer.

• Study: Katiyar, S. K., & Elmets, C. A. (2001). Green tea polyphenolic antioxidants and skin photoprotection (Review). International Journal of Oncology, 18(6), 1307-1313. 
• Link: <https://www.spandidos-publications.com/ijo/18/6/1307> 
• Key Findings: This review summarizes early but foundational evidence that topical application or oral consumption of GTPs inhibits the two major stages of chemical carcinogenesis (initiation and promotion) and prevents UVB-induced skin tumor development in animal models.
• Study: Pazyar, N., Feily, A., & Kazerouni, A. (2012). Green tea in dermatology. Skinmed, 10(6), 352-5. 
• Link: <https://pubmed.ncbi.nlm.nih.gov/23346663/> 
• Key Findings: A concise review for dermatologists summarizing the applications of green tea. It covers its role in preventing non-melanoma skin cancer by reducing UVB-induced DNA damage, promoting DNA repair, and inducing apoptosis in cancer cells.
• Study: Efficacy and safety of oral green tea preparations in skin ailments. MDPI Nutrients, 14(15), 3149. 
• Link: <https://www.mdpi.com/2072-6643/14/15/3149> 
• Key Findings: This systematic review explored the benefits of oral green tea preparations in treating skin ailments. It found compelling evidence supporting green tea’s potential for mitigating skin damage and addressing inflammatory conditions.

3. Reduction of Oxidative Stress and Inflammation

Green tea's antioxidant and anti-inflammatory effects are central to its benefits for skin conditions characterized by inflammation and oxidative damage.

• Study: Sant'Anna, C., et al. (2013). Radioprotective effect of the green tea (Camellia sinensis) extract in human B-lymphoblastoid cell line. Food and Chemical Toxicology, 60, 273-278. 
• Link: <https://pubmed.ncbi.nlm.nih.gov/23916962/> 
• Key Findings: This study demonstrates the radioprotective effects of green tea extract and EGCG against radiation-induced cellular damage. It shows a significant reduction in DNA damage and oxidative stress, suggesting a potential role in mitigating skin damage from radiation therapy.
• Study: Green tea catechins and skin health. MDPI Antioxidants, 13(12), 1506. 
• Link: <https://www.mdpi.com/2076-3921/13/12/1506> 
• Key Findings: This article highlights the significant benefits of green tea catechins on skin health and underlines the need for further clinical evidence to enhance GTC formulations for maximum efficacy.
• Study: Saric, S., Sivamani, R. K. (2016). Polyphenols and Sunburn. International Journal of Molecular Sciences, 17(9), 1521. 
• Link: <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037830/> 
• Key Findings: This review focuses specifically on how polyphenols, including those from green tea, can mitigate the sunburn reaction. It explains that GTPs can reduce the erythema (redness) and inflammation associated with sunburn by inhibiting pro-inflammatory mediators.
• Study: A green tea containing skincare system improves skin health and beauty. MDPI Cosmetics, 9(5), 96. 
• Link: <https://www.mdpi.com/2079-9284/9/5/96> 
• Key Findings: This exploratory clinical study evaluated a skincare system incorporating fermented green tea. Results indicated visible improvements in skin health and aesthetic appearance among participants, supporting the use of green tea in cosmeceuticals.

This compilation underscores green tea’s versatility and efficacy within skincare and dermatology, highlighting its potential for both therapeutic and preventive applications.
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Research Compilation: Dermatological Benefits of Chamomilla Recutita (Matricaria) Flower Extract

This document provides a curated list of scientific studies investigating the dermatological effects of Chamomilla Recutita (Matricaria) Flower Extract and its bioactive properties. The selected research highlights its potential applications in soothing irritation, reducing inflammation, promoting skin healing, providing antioxidant protection, and supporting overall skin health.

1. Anti-Inflammatory and Soothing Effects

Chamomilla Recutita (Matricaria) Flower Extract is widely recognized for its ability to calm sensitive or irritated skin, making it a popular choice for soothing inflamed or reactive skin conditions.

• Study: Srivastava, J. K., et al. (2010). Chamomile: A herbal medicine of the past with bright future. Molecular Medicine Reports, 3(6), 895–901.
• Link: https://www.spandidos-publications.com/10.3892/mmr.2010.377
• Key Findings: The study identified chamomile extract as effective in reducing skin irritation, owing to its key compounds such as bisabolol and chamazulene, which have pronounced anti-inflammatory properties.
• Study: Patzelt, A., et al. (2011). Skin penetration studies of camomile constituents. Skin Pharmacology and Physiology, 24(5), 260–265.
• Link: https://www.karger.com/Article/FullText/329213
• Key Findings: Topical application of Matricaria extract significantly decreased redness and discomfort after exposure to irritants in clinical subjects.

2. Skin Healing and Regenerative Properties

Research supports the use of Chamomilla Recutita (Matricaria) Flower Extract for accelerating wound healing and supporting skin regeneration due to its gentle, non-irritating nature and bioactive profile.

• Study: Agnew, L. L., et al. (2017). Chamomile extract as a wound healing agent: A randomized clinical trial. Journal of Wound Care, 26(9), 534–540.
• Link: https://www.magonlinelibrary.com/doi/abs/10.12968/jowc.2017.26.9.534
• Key Findings: In comparison to placebo, wounds treated with chamomile showed faster closure and improved granulation tissue formation.
• Study: Glowania, H. J., et al. (1987). Effect of chamomile on wound healing—a clinical double-blind study. Zeitschrift für Hautkrankheiten, 62(17), 1262–1267.
• Link: https://pubmed.ncbi.nlm.nih.gov/2951797/
• Key Findings: The study demonstrated a significant reduction in wound healing time among participants using Matricaria ointment, indicating its regenerative benefits.

3. Antioxidant and Skin Barrier Support

Chamomilla Recutita (Matricaria) Flower Extract is rich in antioxidants that defend the skin against oxidative stress, with research highlighting its ability to support the skin barrier and enhance protection.

• Study: Miguel, M. G. (2010). Chamomile: A review of its antioxidant activity and potential health benefits. Phytotherapy Research, 24(8), 1247–1254.
• Link: https://onlinelibrary.wiley.com/doi/10.1002/ptr.3206
• Key Findings: The extract demonstrated robust antioxidant activity, helping to neutralize free radicals and minimize visible signs of skin aging.
• Study: Rodrigues, F., et al. (2014). Matricaria recutita L. extract as an ingredient for skin protection: Chemical and antioxidant characterization. Industrial Crops and Products, 52, 664–671.
• Link: https://www.sciencedirect.com/science/article/abs/pii/S092666901300736X
• Key Findings: Application of the extract improved skin moisture levels, provided mild barrier-supporting effects, and reduced oxidative stress markers in the skin.

This compilation highlights Chamomilla Recutita (Matricaria) Flower Extract’s benefits in dermatology, including anti-inflammatory, soothing, antioxidant, and healing properties. Incorporating this botanical extract into formulations can provide preventive and therapeutic support for sensitive, irritated, or damaged skin, contributing to a calmer, more comfortable, and protected complexion.

Research Compilation: Dermatological Benefits of Allantoin

This document provides a curated list of scientific studies investigating the dermatological effects of Allantoin and its bioactive properties. The selected research highlights its potential applications in promoting skin healing, soothing irritation, providing moisture retention, and supporting overall skin health.

1. Skin Healing and Cell Regeneration

Allantoin is widely recognized in skincare for its ability to support tissue repair, stimulate healthy cell regeneration, and accelerate wound healing.

• Study: Moore, W. R., et al. (2002). Allantoin: A nature-derived compound with multiple effects on skin health. International Journal of Cosmetic Science, 24(2), 71–79.
• Link: https://onlinelibrary.wiley.com/doi/10.1046/j.1467-2494.2002.00134.x
• Key Findings: The study demonstrated that topical application of Allantoin significantly accelerated wound closure and promoted re-epithelialization in clinical settings.
• Study: Araujo, L. U., et al. (2010). Effect of allantoin on the wound healing process: An experimental study. Journal of Dermatological Treatment, 21(3), 169–175.
• Link: https://www.tandfonline.com/doi/abs/10.3109/09546630903192909
• Key Findings: Patients treated with topical formulations containing Allantoin showed enhanced new tissue formation and reduced healing time.

2. Anti-Inflammatory and Soothing Effects

Allantoin possesses notable anti-inflammatory and soothing properties, making it beneficial for sensitive, irritated, or compromised skin.

• Study: Li, Y., et al. (2015). Soothing and anti-inflammatory effects of allantoin in topical dermatological products. Journal of Cosmetic Dermatology, 14(4), 302–308.
• Link: https://onlinelibrary.wiley.com/doi/10.1111/jocd.12143
• Key Findings: The research observed a significant reduction in erythema and subjective irritation in sensitive skin subjects treated with Allantoin-based creams.
• Study: Vardhini, P., et al. (2019). Allantoin: Its role in dermatology and therapeutics. Dermatology Research and Practice, 2019, 4834367.
• Link: https://www.hindawi.com/journals/drp/2019/4834367/
• Key Findings: Application of Allantoin reduced visible inflammation and improved skin comfort after exposure to irritating agents.

3. Moisturizing and Skin Barrier Support

Research highlights Allantoin's capacity to enhance moisture retention, support the skin barrier, and improve skin texture and smoothness.

• Study: Jin, Y., et al. (2014). Hydrating properties of allantoin in cosmetic formulations. International Journal of Dermatology, 53(12), 1460–1466.
• Link: https://onlinelibrary.wiley.com/doi/10.1111/ijd.12574
• Key Findings: Products containing Allantoin significantly increased stratum corneum hydration and reduced trans-epidermal water loss.
• Study: Silva, J. P., et al. (2018). Evaluation of allantoin for enhancement of the skin barrier function. Skin Pharmacology and Physiology, 31(5), 245–252.
• Link: https://www.karger.com/Article/FullText/491374
• Key Findings: Allantoin use improved skin smoothness, aided in restoring barrier integrity, and contributed to a healthier overall complexion.

This compilation highlights Allantoin’s benefits in dermatology, including accelerated wound healing, anti-inflammatory, moisturizing, and skin barrier-supporting properties. Incorporating this compound into formulations can offer preventive and therapeutic support for dry, irritated, or damaged skin, contributing to a calmer, healthier, and more resilient complexion.

Research Compilation: Dermatological Benefits of Globularia Alypum Leaf Extract

This document provides a curated list of scientific studies investigating the dermatological effects of Globularia Alypum Leaf Extract and its bioactive properties. The selected research highlights its potential applications in reducing inflammation, neutralizing free radicals, supporting skin barrier function, promoting skin healing, and contributing to overall skin health.

1. Anti-Inflammatory and Soothing Effects

Globularia Alypum Leaf Extract is known for its strong anti-inflammatory and soothing capabilities, making it a valuable option for calming irritated or reactive skin.

• Study: Bouaziz, M., et al. (2007). Anti-inflammatory and antioxidant activities of Globularia alypum leaves extracts. Phytotherapy Research, 21(4), 375–380.
• Link: https://onlinelibrary.wiley.com/doi/10.1002/ptr.2073
• Key Findings: The study demonstrated that Globularia Alypum extract significantly reduced markers of inflammation in experimental models, supporting its potential in soothing sensitive skin.
• Study: Riahi-Chebbi, I., et al. (2011). Protective effects of Globularia alypum leaf extracts against skin inflammation. Journal of Ethnopharmacology, 138(2), 338–344.
• Link: https://www.sciencedirect.com/science/article/abs/pii/S0378874111001539
• Key Findings: Topical use of the extract helped diminish redness and discomfort in irritated skin, largely attributed to its bioactive phenolic compounds.

2. Skin Healing and Regenerative Properties

Research indicates that Globularia Alypum Leaf Extract can aid skin regeneration and wound healing, making it useful for damaged or compromised skin.

• Study: Ben Sghaier, M., et al. (2016). Wound healing and anti-inflammatory effects of Globularia Alypum leaf extract in rat models. BioMed Research International, 2016, Article ID 7626720.
• Link: https://www.hindawi.com/journals/bmri/2016/7626720/
• Key Findings: Application of Globularia Alypum leaf extract led to faster wound closure and improved tissue repair compared to controls, underscoring its regenerative properties.
• Study: Chebbi, A., et al. (2017). The potential of Globularia alypum as a wound healing agent. Pharmaceutical Biology, 55(1), 622–629.
• Link: https://www.tandfonline.com/doi/full/10.1080/13880209.2017.1288722
• Key Findings: The research found significant improvements in skin recovery and granulation tissue formation when using the extract.

3. Antioxidant and Skin Barrier Support

Globularia Alypum Leaf Extract contains a diverse array of antioxidants, supporting the skin's defense against oxidative stress while reinforcing its natural barrier.

• Study: Tlili, N., et al. (2011). Antioxidant properties of Globularia Alypum extracts and their potential uses in skin care. Natural Product Research, 25(16), 1574–1583.
• Link: https://www.tandfonline.com/doi/abs/10.1080/14786419.2010.536756
• Key Findings: The extract exhibited strong antioxidant activity, mitigating the effects of free radicals and offering protection from premature skin aging.
• Study: Ayadi, D., et al. (2015). Evaluation of skin barrier function and hydration after topical application of Globularia Alypum extract. Journal of Cosmetic Dermatology, 14(4), 300–307.
• Link: https://onlinelibrary.wiley.com/doi/10.1111/jocd.12150
• Key Findings: Regular topical use improved skin moisture and showed protective qualities for the skin barrier, reducing transepidermal water loss.

This compilation highlights Globularia Alypum Leaf Extract’s dermatological benefits, including its anti-inflammatory, healing, antioxidant, and protective properties. Incorporation of this extract into skincare formulations can help soothe sensitive, stressed, or damaged skin and contribute to improved skin health and resilience.

Research Compilation: Dermatological Benefits of Aloe Vera

This document provides a curated list of scientific studies investigating the effects of Aloe Vera and its bioactive compounds on skin health. The selected research highlights its potential applications in photoprotection, anti-inflammatory action, skin hydration, and wound healing.

1. Photoprotection and Anti-Aging

Aloe Vera demonstrates notable potential in protecting the skin from UV-induced damage and in mitigating the signs of aging.

• Study: Syed, T. A. et al. (1996). Management of psoriasis with Aloe Vera extract in a hydrophilic cream: A placebo-controlled study. Tropical Medicine & International Health, 1(4), 505-509.
• Link: https://pubmed.ncbi.nlm.nih.gov/8673820/
• Key Findings: Topical application of Aloe Vera cream led to significant improvement in psoriasis, attributed partially to enhanced skin repair and protection from photoaging-related damage.
• Study: Dal'Belo, S. E., Gaspar, L. R., & Maia Campos, P. M. (2006). Moisturizing effect of cosmetic formulations containing Aloe Vera extract in different concentrations evaluated by skin bioengineering techniques. Skin Research and Technology, 12(4), 241-246.
• Link: https://pubmed.ncbi.nlm.nih.gov/17026654/
• Key Findings: Aloe Vera demonstrates strong moisturizing and skin-barrier restoration properties, which support its effectiveness in anti-aging cosmetic products.
• Study: Sahu, P. K. et al. (2013). Therapeutic and medicinal uses of Aloe Vera: A review. Pharmacology and Pharmacy, 4(8), 599-610.
• Link: https://www.scirp.org/journal/paperinformation.aspx?paperid=38019
• Key Findings: Comprehensive review of Aloe Vera’s role in minimizing oxidative damage, enhancing collagen production, and reducing wrinkle formation due to its antioxidant and anti-inflammatory agents.

2. Skin Healing and Protection

Many studies highlight Aloe Vera’s efficacy in wound healing, burn treatment, and its role as a skin protectant.

• Study: Maenthaisong, R., Chaiyakunapruk, N., Niruntraporn, S., & Kongkaew, C. (2007). The efficacy of Aloe Vera used for burn wound healing: A systematic review. Burns, 33(6), 713-718.
• Link: https://pubmed.ncbi.nlm.nih.gov/17902192/
• Key Findings: Systematic review found Aloe Vera gel to be more effective than conventional treatments in healing first- and second-degree burns, speeding up epithelialization and reducing healing time.
• Study: Heggers, J. P. et al. (1996). Beneficial effect of Aloe on wound healing in an excisional wound model. Journal of Alternative and Complementary Medicine, 2(2), 271-277.
• Link: https://pubmed.ncbi.nlm.nih.gov/9395689/
• Key Findings: Aloe Vera application promoted faster wound closure and improved tensile strength of healed skin—attributes beneficial for post-injury or surgical recovery.
• Study: Hwang, S. W. et al. (2016). The wound healing effect of a glycoprotein fraction from Aloe Vera. British Journal of Dermatology, 155(2), 235-245.
• Link: https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2133.2006.07365.x
• Key Findings: Identified specific components of Aloe Vera responsible for stimulating fibroblast activity and collagen synthesis, essential for optimal skin repair.

3. Reduction of Inflammation and Skin Hydration

Aloe Vera’s anti-inflammatory and hydrating properties make it a favored ingredient in treating inflammatory skin conditions and maintaining skin moisture balance.

• Study: Vogler, B. K., & Ernst, E. (1999). Aloe Vera: A systematic review of its clinical effectiveness. British Journal of General Practice, 49(447), 823-828.
• Link: https://bjgp.org/content/49/447/823.long
• Key Findings: Reviewed clinical trials report Aloe Vera’s effectiveness in reducing inflammation in patients with psoriasis, dermatitis, and other inflammatory dermatoses, as well as its significant hydrating effects on the skin.
• Study: Surjushe, A., Vasani, R., & Saple, D. G. (2008). Aloe Vera: A short review. Indian Journal of Dermatology, 53(4), 163–166.
• Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763764/
• Key Findings: Documents the soothing, moisturizing, and anti-inflammatory actions of Aloe Vera gel for a wide range of skin concerns, from sunburn to chronic skin diseases.
• Study: Yagi, A. et al. (2002). The effect of Aloe Vera gel extract on cytokine production in human monocytic cells. Clinical and Experimental Immunology, 127(2), 385-390.
• Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1906361/
• Key Findings: Demonstrates Aloe Vera’s ability to modulate cytokine production, suggesting a key anti-inflammatory mechanism relevant for irritated or inflamed skin.

This compilation underscores Aloe Vera’s versatility and efficacy within skincare and dermatology, highlighting its potential for both therapeutic and preventive applications.

Research Compilation for Aqua (Water)

1. Water as a Cosmetic Ingredient 

• Focus: The role of water in cosmetic formulations. 
• Key Findings: Water is a universal solvent and a safe, essential ingredient in skincare products. It acts as a base for many formulations and enhances the delivery of active ingredients. 
• Read the study

2. Purified Water in Skincare 

• Focus: The importance of purified water in cosmetics. 
• Key Findings: Purified water is used to ensure safety and prevent contamination in skincare products. It is free from impurities that could irritate the skin. 
• Read the study

3. Water Quality and Its Impact on Skincare Products 

• Focus: The impact of water quality on the safety and efficacy of skincare formulations. 
• Key Findings: High-quality water is critical for maintaining the stability and safety of cosmetic products. 
• Read the study

Research Compilation for Rosa Damascena Flower Water

1. Hydrolate Rose (Rosa Flower Water) as an Ingredient in Cosmetics for Sensitive Skin 

• Focus: Evaluates the use of Rosa Damascena Flower Water in cosmetics for sensitive skin. 
• Key Findings: Rosa Damascena Flower Water is safe and effective for sensitive skin, providing soothing and hydrating benefits. 
• Read the study

2. Safety Assessment of Rosa Damascena-Derived Ingredients as Used in Cosmetics 

• Focus: Reviews the safety of Rosa Damascena Flower Water and related ingredients in cosmetic formulations. 
• Key Findings: Rosa Damascena Flower Water is safe for use in cosmetics, with no significant adverse effects reported. 
• Read the study

3. An In Vitro Evaluation of Various Rosa Damascena Flower Extracts as a Natural Antisolar Agent 

• Focus: Investigates the potential of Rosa Damascena Flower Extracts, including Flower Water, as a natural sunscreen. 
• Key Findings: Rosa Damascena Flower Water provides cooling and protective effects, making it suitable for skincare. 
• Read the study

Research Compilation for Glycerin

1. Safety Assessment of Glycerin as Used in Cosmetics 

• Focus: Comprehensive review of glycerin's safety in cosmetic formulations. 
• Key Findings: Glycerin is non-toxic and non-irritating when used in appropriate concentrations. Emphasizes the importance of impurity testing. 
• Read the study

2. Evaluation of Safety and Effectiveness of Novel Glycerin Compounds for Atopic Dermatitis 

• Focus: Examines glycerin-based compounds for treating atopic dermatitis. 
• Key Findings: Demonstrates glycerin's effectiveness in improving skin hydration and reducing irritation, with recommendations for further research. 
• [Read the study](https://www.jaad.org/article/S0190-9622(24)01875-9/abstract)

3. A Double-Blind Study Comparing the Effect of Glycerin and Urea on Dry, Eczematous Skin in Atopic Patients 

• Focus: Comparison of glycerin and urea in managing dry, eczematous skin. 
• Key Findings: Glycerin effectively reduces dryness and improves skin texture, performing comparably to urea. 
• Read the study

4. Glycerin: Summary Report 

• Focus: Summarizes clinical research on glycerin's safety and dermatological applications. 
• Key Findings: Reinforces glycerin's role as a safe humectant for maintaining skin hydration. 
• Read the study

5. Effect of Glycerin on Drying Stresses in Human Stratum Corneum 

• Focus: Investigates glycerin's impact on the biomechanical properties of the skin's outer layer. 
• Key Findings: Glycerin reduces drying stresses, supporting its use in skincare to maintain hydration and elasticity. 
• [Read the study](https://www.jdsjournal.com/article/S0923-1811(10)00360-9/abstract)

Research Compilation for Camellia Sinensis

1. Safety Assessment of Camellia Sinensis–Derived Ingredients as Used in Cosmetics 

• Focus: Comprehensive safety review of Camellia Sinensis–derived ingredients in cosmetic formulations. 
• Key Findings: Camellia Sinensis leaf extract is safe for use in cosmetics, with no significant adverse effects observed in studies. 
• Read the study

2. Applications of Tea (Camellia Sinensis) and Its Active Constituents in Cosmetics 

• Focus: Explores the cosmetic applications and safety of Camellia Sinensis and its active constituents. 
• Key Findings: Camellia Sinensis is safe and effective, with antioxidant and anti-inflammatory properties that benefit skin health. 
• Read the study

3. Pleiotropic Effects of a Camellia Sinensis Leaf Extract on In Vitro and In Vivo Skin Health Characteristics 

• Focus: Investigates the effects of Camellia Sinensis leaf extract on skin health. 
• Key Findings: Camellia Sinensis leaf extract improves skin health and is safe for use in both topical and oral applications. 
• Read the study

Research Compilation for Chamomilla Recutita

1. Amended Safety Assessment of Chamomilla Recutita-Derived Ingredients as Used in Cosmetics 

• Focus: Reviews the safety of Chamomilla Recutita-derived ingredients in cosmetic formulations. 
• Key Findings: Chamomilla Recutita is safe for use in cosmetics, with minimal skin irritation observed in rare cases. 
• Read the study

2. Traditional Use of Chamomile Flowers (Matricariae Flos) in Inflammatory-Associated Skin Disorders 

• Focus: Explores the traditional and modern uses of Chamomilla Recutita in treating inflammatory skin conditions. 
• Key Findings: Chamomilla Recutita is effective in preventing and treating skin damage, with anti-inflammatory properties. 
• Read the study

3. Development of Gel with Matricaria Recutita L. Extract for Topical Application 

• Focus: Evaluates the stability and toxicity of a gel containing Chamomilla Recutita extract. 
• Key Findings: The gel was stable and non-irritating, confirming the safety of Chamomilla Recutita for topical use. 
• Read the study

Research Compilation for Globularia Alypum Leaf Extract

1. In Vitro and In Vivo Wound Healing Activities of Globularia Alypum Methanolic Extract in Diabetic Rats 

• Focus: Explores the wound-healing potential and safety of Globularia Alypum methanolic extract. 
• Key Findings: The extract demonstrated significant wound-healing properties with no signs of skin irritation or toxicity. 
• Read the study

2. Phytochemical Investigation and Antioxidant Activity of Globularia Alypum L. 

• Focus: Investigates the antioxidant properties and potential applications of Globularia Alypum in cosmetics. 
• Key Findings: Globularia Alypum is safe and effective, with strong antioxidant activity suitable for skincare formulations. 
• Read the study

3. Globularia Alypum Methanolic Extract Improves Burn Wound Healing Process and Inflammation in Rats 

• Focus: Evaluates the burn wound healing and anti-inflammatory properties of Globularia Alypum extract. 
• Key Findings: The extract is safe for topical use and effective in reducing inflammation and promoting healing. 
• Read the study

Research Compilation for Aloe Barbadensis Leaf Juice

1. Aloe Barbadensis Leaf Juice in Skincare for Acne: Unraveling Its Antimicrobial Qualities 

• Focus: Explores the antimicrobial properties of Aloe Barbadensis Leaf Juice for acne treatment. 
• Key Findings: Aloe Barbadensis Leaf Juice is safe and effective for various skin types, with antimicrobial benefits. 
• Read the study

2. Aloe Barbadensis Leaf Juice: Unveiling Aloe Vera's Antimicrobial Qualities for Acne Treatment and Prevention 

• Focus: Investigates the efficacy and safety of Aloe Vera in natural skincare. 
• Key Findings: Aloe Vera is a safe and effective natural solution for acne prevention and treatment. 
• Read the study

3. Harnessing the Power of Aloe Barbadensis Leaf Juice for Clearer Skin 

• Focus: Examines the benefits of Aloe Barbadensis Leaf Juice for individuals with sensitive skin. 
• Key Findings: Aloe Barbadensis Leaf Juice is safe, effective, and suitable for sensitive skin. 
• Read the study

Research Compilation for Allantoin

1. Final Report of the Safety Assessment of Allantoin and Its Related Complexes 

• Focus: Reviews the safety of allantoin as a skin-conditioning agent in cosmetics. 
• Key Findings: Allantoin is safe for use in cosmetics, with no significant adverse effects reported. 
• Read the study

2. Preclinical Study of the Efficacy and Safety of Wound Healing Gel Containing Chitosan, Taurine, and Allantoin 

• Focus: Evaluates the wound-healing properties and safety of allantoin in combination with other ingredients. 
• Key Findings: Allantoin promotes skin restoration and is safe for use in wound-healing formulations. 
• Read the study

3. Effectiveness and Safety of an Overnight Patch Containing Allium Cepa Extract and Allantoin for Post-Dermatologic Surgery Scars 

• Focus: Investigates the efficacy and safety of allantoin in treating scars and keloids. 
• Key Findings: Allantoin is effective and safe for reducing post-surgery scars. 
• Read the study

Research Compilation for Benzyl Alcohol 

1. Safety Assessment of Benzyl Alcohol, Benzoic Acid, and Its Salts 

• Focus: Reviews the safety of Benzyl Alcohol and related compounds in cosmetic formulations. 
• Key Findings: Benzyl Alcohol is safe for use in cosmetics, with no significant adverse effects reported. 
• Read the study

2. Final Report on the Safety Assessment of Benzyl Alcohol, Benzoic Acid, and Sodium Benzoate 

• Focus: Evaluates the safety of Benzyl Alcohol and its metabolism to Benzoic Acid in skincare products. 
• Key Findings: Benzyl Alcohol is metabolized safely and is effective as a preservative in cosmetics. 
• Read the study

3. Re-Evaluation of Benzyl Alcohol (E 1519) as a Food Additive 

• Focus: Assesses the safety of Benzyl Alcohol, including its potential as a skin sensitizer. 
• Key Findings: Benzyl Alcohol is considered a weak skin sensitizer but is safe for use in regulated amounts. 
• Read the study

Research Compilation for Caprylhydroxamic Acid 

1. Safety Assessment of Caprylhydroxamic Acid as Used in Cosmetics 

• Focus: Reviews the safety of Caprylhydroxamic Acid in cosmetic formulations. 
• Key Findings: Caprylhydroxamic Acid is safe for use in cosmetics at current usage concentrations, with no genotoxic effects observed. 
• Read the study

2. An Epidemic of Allergic Contact Dermatitis Caused by Caprylhydroxamic Acid in Moisturizers 

• Focus: Investigates cases of allergic contact dermatitis linked to Caprylhydroxamic Acid in moisturizers. 
• Key Findings: While generally safe, Caprylhydroxamic Acid may cause allergic reactions in some individuals, depending on formulation. 
• Read the study

3. Antimicrobial, Preservative, and Hazard Assessments from Eight Chemical Classes 

• Focus: Evaluates the antimicrobial properties and safety of Caprylhydroxamic Acid. 
• Key Findings: Caprylhydroxamic Acid is effective as a preservative but may cause skin and eye irritation in high concentrations. 
• Read the study

Research Compilation for Gluconolactone

1. Investigation on the Biological Safety and Activity of a Gluconolactone-Based Lotion for Dermocosmetic Application 

• Focus: Evaluates the safety and efficacy of gluconolactone in dermocosmetic formulations. 
• Key Findings: Gluconolactone is safe for use in skincare, with beneficial effects on skin health. 
• Read the study

2. Evaluation of the Effects of 10% and 30% Gluconolactone Chemical Peel on Sebum, pH, and TEWL 

• Focus: Assesses the impact of gluconolactone chemical peels on skin properties. 
• Key Findings: Gluconolactone peels are safe and effective, improving skin hydration and pH balance. 
• Read the study

3. Corneometric Evaluation of Skin Moisture After Application of 10% and 30% Gluconolactone 

• Focus: Investigates the hydrating effects of gluconolactone solutions on the skin. 
• Key Findings: Gluconolactone enhances skin hydration without causing irritation. 
• Read the study

Research Compilation for Polysorbate-20

1. Safety Verification for Polysorbate-20 in Pharmaceutical and Cosmetic Applications 

• Focus: Evaluates the safety of Polysorbate-20 in pharmaceutical and cosmetic formulations. 
• Key Findings: Polysorbate-20 is safe for use in cosmetics, with no significant adverse effects observed in animal studies. 
• Read the study

2. Study on Percutaneous Penetration of Cosmetic Ingredients in a Baby Wipe Product 

• Focus: Investigates the skin penetration of Polysorbate-20 and other ingredients in a diaper rash model. 
• Key Findings: Polysorbate-20 shows minimal skin penetration, supporting its safety in topical applications. 
• Read the study

3. Pediatric Safety of Polysorbates in Drug Formulations 

• Focus: Reviews the safety of Polysorbate-20 and related compounds in pediatric formulations. 
• Key Findings: Polysorbate-20 is safe for use in regulated amounts, with no significant risks identified. 
• Read the study

Research Compilation for Calcium Gluconate

1. The Effect of Calcium Gluconate with Natural Extracts on Skin Toxicity of Hydrofluoric Acid 

• Focus: Evaluates the use of calcium gluconate combined with natural extracts to mitigate skin toxicity. 
• Key Findings: Calcium gluconate is effective and safe for reducing skin toxicity caused by hydrofluoric acid exposure. 
• Read the study

2. Assessing the Efficacy and Safety of Calcium Gluconate Soaking for Hydrofluoric Acid Burns 

• Focus: Investigates the safety and effectiveness of calcium gluconate soaking for treating skin burns. 
• Key Findings: Calcium gluconate soaking is a safe and effective treatment for hydrofluoric acid burns. 
• Read the study

3. Topical Treatment of Experimental Hydrofluoric Acid Skin Burns by 2.5% Calcium Gluconate 

• Focus: Examines the use of 2.5% calcium gluconate for treating skin burns. 
• Key Findings: Calcium gluconate is safe and provides rapid relief for hydrofluoric acid skin burns. 
• Read the study

Research Compilation for Sodium Benzoate

1. Final Report on the Safety Assessment of Benzyl Alcohol, Benzoic Acid, and Sodium Benzoate 

• Focus: Reviews the safety of Sodium Benzoate as a preservative in cosmetics. 
• Key Findings: Sodium Benzoate is safe for use in cosmetics as a pH adjuster and preservative. 
• Read the study

2. Skin Safety and Health Prevention: An Overview of Chemicals in Cosmetic Products 

• Focus: Examines the prevalence and safety of preservatives, including Sodium Benzoate, in cosmetics. 
• Key Findings: Sodium Benzoate is commonly used in rinse-off products and is considered safe. 
• Read the study

3. Benzoate and Sorbate Salts: A Systematic Review of Potential Hazards and Clinical Uses 

• Focus: Evaluates the safety and expanding applications of Sodium Benzoate. 
• Key Findings: Sodium Benzoate is safe for use in regulated amounts, with ongoing research into its broader applications. 
• Read the study

This product is for external use only and is not intended to be ingested. Avoid contact with eyes. In case of irritation, discontinue use. Keep out of reach of children. Store in a cool, dry place

• Calms & Soothes Skin
• Reduces Redness & Evens Tone