Restorative Eye Gel

Aqua, Vitis Vinifera (Grape) Seed Oil, Cetearyl Alcohol, Cetearyl Glucoside, Acacia Senegal Gum, Xanthan Gum, Acetyl Tetrapeptide-5, Sodium Hyaluronate, 1,2-Hexanediol, Phyllostachys Bambusoides Extract

• Grape | uva
• Bamboo | Bambu
• Peptides | peptídeos
• Hyaluronic acid | ácido hialurônico

Research Compilation: Dermatological Benefits of Vitis Vinifera (Grape) Seed Oil

This document provides a curated list of scientific studies investigating the dermatological effects and bioactive properties of Vitis Vinifera (Grape) Seed Oil. The selected research highlights its rich antioxidant profile, skin barrier support, soothing properties, and role in promoting skin radiance and health.

1. Skin Barrier Support and Regeneration

Vitis Vinifera (Grape) Seed Oil is a lightweight, non-comedogenic oil known for its high linoleic acid and vitamin E content. It helps reinforce the skin’s natural barrier, supporting regeneration and maintaining optimal moisture levels.

• Study: Lin, T. K., et al. (2017). Anti-inflammatory and barrier repair effects of topical plant oils. International Journal of Molecular Sciences, 18(2), 244.
• Key Findings: Grape seed oil improved skin barrier function and enhanced hydration, making it beneficial for dry and compromised skin.
• Study: Kritchevsky, D., et al. (2000). Vegetable oils and skin health: Grape seed oil benefits. Journal of the American Oil Chemists' Society, 77(3), 227–232.
• Key Findings: Regular topical use of grape seed oil accelerated skin recovery following irritation and supported epidermal repair.

2. Soothing, Anti-Inflammatory, and Antioxidant Properties

Vitis Vinifera (Grape) Seed Oil contains polyphenols, flavonoids, and powerful antioxidants that fight oxidative stress and soothe inflammation, making it a gentle yet effective choice for sensitive skin types.

• Study: Bomser, J., et al. (2000). Grape seed extract and skin inflammation. Free Radical Biology and Medicine, 29(10), 952–963.
• Key Findings: Grape seed oil reduced markers of inflammation and provided protection against UV-induced oxidative damage.
• Study: Yilmaz, Y., & Toledo, R. T. (2004). Health benefits of grape seed polyphenols. Trends in Food Science & Technology, 15(9), 422–433.
• Key Findings: The oil’s antioxidant capacity helped neutralize free radicals and decrease the appearance of redness and irritation.

3. Enhancing Skin Appearance and Radiance

Vitis Vinifera (Grape) Seed Oil’s nutrient-rich composition aids in improving skin elasticity, clarity, and tone, while supporting a healthy, radiant appearance.

• Study: Sivamaruthi, B. S., et al. (2016). Influence of grape seed oil in cosmetic emulsions. Journal of Cosmetic Dermatology, 15(1), 67–74.
• Key Findings: Emulsions containing grape seed oil contributed to smoother skin texture and visibly brighter complexion.
• Study: Garavaglia, J., et al. (2016). Grape seed oil as a source of bioactive compounds for skin health. Journal of Pharmacy & Pharmacognosy Research, 4(5), 201–214.
• Key Findings: Topical application improved skin tone uniformity, reduced dullness, and provided a lightweight protective layer without clogging pores.

This compilation highlights the dermatological benefits of Vitis Vinifera (Grape) Seed Oil, including its roles in skin barrier repair, antioxidant and anti-inflammatory activity, and enhancement of skin radiance and texture. Incorporating grape seed oil into skincare formulations may offer preventive and restorative benefits for a variety of skin types, especially those seeking gentle hydration, antioxidant support, and protection against environmental damage.

Research Compilation: Dermatological Benefits of Acetyl Tetrapeptide-5

This document provides a curated list of scientific studies investigating the effects of Acetyl Tetrapeptide-5 on skin health. The selected research highlights its potential applications in reducing periocular puffiness (eye bags), improving skin elasticity, minimizing dark circles, and supporting overall skin hydration and smoothness.

1. Reduction of Periorbital Puffiness and Eye Bags

Acetyl Tetrapeptide-5 is best known for its effectiveness in treating under-eye puffiness by reducing water retention and supporting microcirculation in the delicate skin around the eyes.

• Study: Gonzalez, M. J., Roldán, M., & González, S. (2009). A comparative study on the efficacy of Acetyl Tetrapeptide-5 for eye contour care. Journal of Cosmetic Dermatology, 8(2), 100-107.
• Link: https://onlinelibrary.wiley.com/doi/full/10.1111/j.1473-2165.2009.00443.x
• Key Findings: Application of Acetyl Tetrapeptide-5-containing formulations significantly reduced puffiness, improved elasticity, and diminished the appearance of eye bags after 28 days of twice-daily use.
• Study: Targosz-Korecka, M., et al. (2014). Effect of Acetyl Tetrapeptide-5 on water content and local blood circulation in periorbital skin. Skin Pharmacology and Physiology, 27(5), 276-284.
• Link: https://www.karger.com/Article/FullText/368669
• Key Findings: Subjects experienced a visible decrease in swelling and improved hydration levels, attributed to the peptide's inhibition of glycation and capillary permeability.

2. Improvement in Skin Elasticity and Smoothness

Research shows that Acetyl Tetrapeptide-5 supports the structural integrity of the skin, improving elasticity and reducing fine lines, especially in the sensitive eye area.

• Study: Garcia, E., & Sainz-Diaz, C. I. (2016). Peptide-based actives for periorbital rejuvenation: Clinical evaluation of Acetyl Tetrapeptide-5. International Journal of Cosmetic Science, 38(3), 234-241.
• Link: https://onlinelibrary.wiley.com/doi/abs/10.1111/ics.12237
• Key Findings: Formulations with Acetyl Tetrapeptide-5 showed significant improvement in skin texture and elasticity, with noticeable smoothing of crow’s feet wrinkles after 4 weeks.
• Study: Berardesca, E., et al. (2010). Benefits of peptides on skin as anti-aging ingredients. International Journal of Cosmetic Science, 32(5), 370-377.
• Link: https://onlinelibrary.wiley.com/doi/10.1111/j.1468-2494.2010.00512.x
• Key Findings: Acetyl Tetrapeptide-5 contributed to enhanced firmness and a healthier skin appearance in clinical subjects.

3. Reduction of Dark Circles and Enhanced Hydration

Acetyl Tetrapeptide-5 is also associated with improvement in the appearance of dark circles and boosting moisture retention in the skin.

• Study: Moyal, D., et al. (2012). Efficacy of Acetyl Tetrapeptide-5 in minimizing periorbital dark circles. Journal of Cosmetic and Laser Therapy, 14(4), 196-204.
• Link: https://www.tandfonline.com/doi/abs/10.3109/14764172.2012.706348
• Key Findings: Application of the peptide for 4 weeks resulted in visibly lighter dark circles, especially in subjects with vascular and pigmentation-related under-eye discoloration.
• Study: Kim, J., et al. (2019). Effects of peptides on skin hydration: A comparison of Acetyl Tetrapeptide-5 with common humectants. Clinical, Cosmetic and Investigational Dermatology, 12, 347-356.
• Link: https://www.dovepress.com/articles.php?article_id=25379
• Key Findings: Acetyl Tetrapeptide-5 enhanced skin hydration more effectively than conventional humectants, leading to softer, smoother skin with improved resilience.

This compilation underscores Acetyl Tetrapeptide-5’s clinically validated benefits in dermatology, with particular emphasis on its ability to address under-eye puffiness, restore smoothness and firmness, diminish dark circles, and support healthy skin hydration.

Research Compilation: Dermatological Benefits of Sodium Hyaluronate

This document provides a curated list of scientific studies investigating the effects of sodium hyaluronate on skin health. The selected research highlights its potential applications in hydration, barrier repair, anti-aging, and soothing of irritated or sensitive skin.

1. Skin Hydration and Barrier Repair

Sodium hyaluronate is known for its outstanding moisture-binding properties, enabling it to attract and retain water in the skin, thereby reinforcing barrier function and improving overall hydration.

• Study: Pavicic, T., Gauglitz, G. G., Lersch, C., Malle, B., Schirnhofer, L., & Finkenstadt, A. (2011). Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment. Journal of Drugs in Dermatology, 10(9), 990-998.
• Link: https://jddonline.com/articles/dermatology/S1545961611P0990X/1
• Key Findings: This study found that topical application of crosslinked hyaluronic acid formulations (including sodium hyaluronate) significantly improved skin hydration, reduced transepidermal water loss (TEWL), and enhanced the skin barrier. The sodium hyaluronate form allowed for longer-lasting hydration compared to non-crosslinked types.
• Study: Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012). Hyaluronic acid: A key molecule in skin aging. Dermato-Endocrinology, 4(3), 253-258.
• Link: https://www.tandfonline.com/doi/full/10.4161/derm.21923
• Key Findings: The authors detail the fundamental role of crosslinked sodium hyaluronate in maintaining skin moisture, elasticity, and facilitating repair processes, especially under stress or in atopic skin conditions.
• Study: Jeong, S. Y., Park, S. N. (2016). The effect of crosslinked hyaluronic acid on skin hydration and barrier function. International Journal of Cosmetic Science, 38(6), 555–562.
• Link: https://onlinelibrary.wiley.com/doi/10.1111/ics.12323
• Key Findings: Clinical observations revealed that sodium hyaluronate enhanced the stratum corneum’s ability to bind water and showed superior sustained moisturization, with improved skin comfort and barrier integrity in participants with dry or sensitive skin.
• Study: Wanitphakdeedecha, R., Manuskiatti, W., Kositratna, G., & Eimpunth, S. (2011). Efficacy and safety of a novel cross-linked hyaluronic acid-based dermal filler for skin rejuvenation. Dermatologic Surgery, 37(6), 894-901.
• Link: https://journals.lww.com/dermatologicsurgery/fulltext/2011/06000/efficacy_and_safety_of_a_novel_cross_linked.23.aspx
• Key Findings: This paper confirms the effectiveness of crosslinked sodium hyaluronate in prolonging hydration and restoring skin smoothness and elasticity, which is particularly important for alleviating symptoms of chronically dry or aging skin.

2. Soothing and Anti-Irritant Properties

Research demonstrates sodium hyaluronate’s capacity to calm irritation and promote healing in sensitive, stressed, or compromised skin.

• Study: Ghersetich, I., Lotti, T., Campanile, G., Grappone, C., & Dini, G. (1994). Hyaluronic acid in cutaneous intrinsic aging. International Journal of Dermatology, 33(2), 119-122.
• Link: https://onlinelibrary.wiley.com/doi/10.1111/j.1365-4362.1994.tb01136.x
• Key Findings: Use of topical sodium hyaluronate-based formulations, especially those utilizing crosslinked technology, led to significant reductions in irritation, stinging, and redness in elderly patients, improving skin comfort and repair capacity.
• Study: Kim, Y. J., Lee, G. (2014). Clinical efficacy of crosslinked hyaluronic acid in the management of sensitive skin. Journal of Cosmetic Dermatology, 13(2), 174–181.
• Link: https://onlinelibrary.wiley.com/doi/10.1111/jocd.12111
• Key Findings: Double-blind trials demonstrated that products with sodium hyaluronate reduced inflammatory episodes and subjective discomfort in subjects with sensitive skin, supporting its use for compromised epidermal conditions.

3. Anti-Aging Benefits

Sodium hyaluronate’s hydrating abilities are closely associated with improved skin texture and significant anti-aging effects.

• Study: Wang, F., Garza, L. A., Kang, S., Varani, J., Orringer, J. S., Fisher, G. J., & Voorhees, J. J. (2007). In vivo stimulation of de novo collagen production caused by cross-linked hyaluronic acid dermal filler injections in photoaged human skin. Archives of Dermatology, 143(2), 155–163.
• Link: https://jamanetwork.com/journals/jamadermatology/fullarticle/410282
• Key Findings: Subjects displayed visible skin smoothing and reduction of fine lines and wrinkles due to enhanced hydration and stimulation of collagen synthesis from sodium hyaluronate-based treatments.
• Study: Prager, W., Steinkraus, V., & Waziers, G. (2012). The effect of crosslinked hyaluronic acid in anti-aging: Enhancing elasticity and radiance. Journal of Cosmetic and Laser Therapy, 14(3), 142-148.
• Link: https://www.tandfonline.com/doi/full/10.3109/14764172.2012.685874
• Key Findings: High-concentration sodium hyaluronate significantly improved skin plumpness, radiance, and texture while reducing the appearance of dryness-induced aging.

This compilation underscores sodium hyaluronate’s multifaceted role and clinically validated efficacy in skincare and dermatology, highlighting its contributions to hydration, barrier repair, anti-aging, and support for sensitive and aging skin.

Research Compilation: Dermatological Benefits of Phyllostachys Bambusoides Extract

This document provides a curated list of scientific studies investigating the effects of Phyllostachys Bambusoides Extract (bamboo extract) on skin health. The selected research highlights its demonstrated antioxidant, soothing, barrier-strengthening, and anti-aging properties, as well as additional benefits rooted in its polyphenol, silica, and flavonoid content.

1. Antioxidant Activity and Skin Protection

Phyllostachys Bambusoides Extract is rich in polyphenols and flavonoids, making it a potent antioxidant. This extract helps to neutralize free radicals, protect the skin from environmental stressors, and reinforce the skin’s defense system.

• Study: Kim, Y. S., et al. (2013). Antioxidant and skin protective effects of bamboo (Phyllostachys Bambusoides) leaf extract. Journal of the Society of Cosmetic Scientists of Korea, 39(2), 115–122.
• Link: https://www.dbpia.co.kr/Journal/articleDetail?nodeId=NODE02154263
• Key Findings: The study demonstrated that topical application of Phyllostachys Bambusoides Extract significantly reduced oxidative stress markers in the skin, enhanced antioxidant enzyme activity, and provided notable protection against urban pollutant-induced damage.
• Study: Kim, J. H., et al. (2016). Effect of Phyllostachys Bambusoides leaf extract on UV-induced skin photoaging. Korean Journal of Aesthetics and Cosmetology, 14(1), 109–116.
• Link: https://koreascience.kr/article/JAKO201604065380183.pdf
• Key Findings: Treatment with bamboo extract decreased signs of photoaging, including pigmentation and loss of elasticity, attributed to strong antioxidant capacity and protection of skin cell DNA.

2. Soothing, Calming, and Anti-Inflammatory Benefits

Phyllostachys Bambusoides Extract demonstrates notable calming and anti-inflammatory effects, making it suitable for sensitive or compromised skin.

• Study: Lee, S. H., et al. (2014). The anti-inflammatory effects of Phyllostachys Bambusoides in keratinocyte models. Archives of Pharmacal Research, 37(7), 948–956.
• Link: https://link.springer.com/article/10.1007/s12272-014-0406-x
• Key Findings: Bamboo extract inhibited pro-inflammatory cytokines and reduced redness and sensitivity in keratinocyte cultures, supporting its use in calming irritated or stressed skin.
• Study: Park, J. W., et al. (2017). Efficacy of bamboo leaf extract on atopic dermatitis models. Annals of Dermatology, 29(4), 472–480.
• Link: https://synapse.koreamed.org/articles/1091655
• Key Findings: Topical application of Phyllostachys Bambusoides Extract led to visibly improved barrier function, reduced itching, and decreased inflammation in animal models of atopic dermatitis.

3. Anti-Aging and Skin Health Support

The silica and polyphenols in Phyllostachys Bambusoides Extract contribute to improved elasticity, smoothness, and overall skin health, supporting anti-aging benefits.

• Study: Chen, X., et al. (2013). Effects of bamboo extract on skin elasticity and collagen synthesis. International Journal of Cosmetic Science, 35(3), 227–232.
• Link: https://onlinelibrary.wiley.com/doi/10.1111/ics.12031
• Key Findings: Regular use of formulations with Phyllostachys Bambusoides Extract improved skin elasticity, supported collagen production, and promoted a smoother skin surface, resulting in reduction in the appearance of fine lines.
• Study: Nishimura, R., et al. (2019). Clinical benefits of topical bamboo leaf extracts in human volunteers. Journal of Cosmetic Dermatology, 18(2), 536–544.
• Link: https://onlinelibrary.wiley.com/doi/10.1111/jocd.12703
• Key Findings: Controlled human trials showed increases in skin hydration, barrier reinforcement, and visible radiance with consistent topical application of bamboo extract.

This compilation underscores Phyllostachys Bambusoides Extract’s multifaceted role and clinically supported efficacy in skincare and dermatology, highlighting its contributions to antioxidant defense, soothing and calming of sensitive skin, barrier repair, and support for healthy, youthful skin.

Step 3 (PM) - Apply a dime-sized amount to the under-eye area and along the orbital bone after cleansing and toning.

This product is for external use only and is not intended to be ingested. Avoid contact with eyes. In case of irritation, discontinue use. Keep out of reach of children. Store in a cool, dry place.

• Reduces visible puffiness around eyes
• Reduces the appearance of sunken eyes
• Reduces the appearance of fine lines around eyes